Secretin

SCT
Identifiers
Aliases	SCT, entrez:6343, Secretin
External IDs	OMIM: 182099 HomoloGene: 137358 GeneCards: SCT
Gene ontology Molecular function • receptor binding • hormone activity • protein N-terminus binding Cellular component • extracellular region • extracellular space Biological process • positive regulation of cAMP biosynthetic process • brain development • negative regulation of gastrin-induced gastric acid secretion • pancreatic juice secretion • embryonic digestive tract development • positive regulation of somatostatin secretion • positive regulation of pancreatic juice secretion Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6343	n/a
Ensembl	n/a	n/a
UniProt	P09683	n/a
RefSeq (mRNA)	NM_021920	n/a
RefSeq (protein)	NP_068739	n/a
Location (UCSC)	Chr 11: 0.63 – 0.63 Mb	n/a
PubMed search		n/a

6343

n/a

n/a

n/a

P09683

n/a

NM_021920

n/a

NP_068739

n/a

Secretin is a hormone that regulates water homeostasis throughout the body and influences the environment of the duodenum by regulating secretions in the stomach, pancreas, and liver. It is a peptide hormone produced in the S cells of the duodenum, which are located in the intestinal glands. In humans, the secretin peptide is encoded by the SCT gene.

Secretin helps regulate the pH of the duodenum by (1) inhibiting the secretion of gastric acid from the parietal cells of the stomach and (2) stimulating the production of bicarbonate from the centroacinar cells and intercalated ducts of the pancreas. It also stimulates bile production by the liver; the bile emulsifies dietary fats in the duodenum so that pancreatic lipase can act upon them. Meanwhile, in concert with secretin's actions, the other main hormone simultaneously issued by the duodenum, cholecystokinin, is stimulating the gallbladder to contract, delivering its stored bile for the same reason.

...
Wikipedia