Santi Domenico e Sisto

The Church of Santi Domenico e Sisto (Saints Dominic and Sixtus) is one of the titular churches in Rome, Italy in the care of the Roman Catholic Order of Preachers, better known as the Dominicans. It is located at no. 1 Largo Angelicum on the Quirinal Hill on the campus of the Pontifical University of St. Thomas Aquinas (Angelicum), of which it is the University Church.

The titular church is now vacant with the death of the Cardinal Priest of the Church of Saints Dominic and Sixtus, Georges Cottier, O.P., emeritus Theologian of the Pontifical Household who died in 2016. Cottier studied theology and philosophy at the Angelicum obtaining a baccalaurate in philosophy and completing his licentiate in theology in 1952.

The first church at the site, Santa Maria a Magnanapoli, was built sometime before the year 1000.

The present church was built at the order of Dominican Pope Pius V. Construction on the church began in 1569 and on a convent for Dominican nuns in 1575. The original plan was the work of Giacomo della Porta though during the long construction period that stretched until 1663 several other architects were involved. The lower part of the church was designed by Nicola Torriani, and the upper part by Torriani or Vincenzo della Greca. della Greca constructed the Baroque travertine façade in 1646, with his brother Felice.

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