Sanford is a city in York County, Maine, United States. The population was 20,798 in the 2010 census, making it the seventh largest municipality in the state. Situated on the Mousam River, Sanford includes the village of Springvale. The city features many lakes in wooded areas which attract campers.

Sanford is part of the Portland–South Portland–Biddeford, Maine metropolitan statistical area.

On November 6, 2012, Sanford voters approved a new charter to re-incorporate Sanford as a city and replace the town meeting format with a city council/mayor/strong manager form of government, along with other changes. The new charter took effect on January 1, 2013. Sanford's new charter provides that the first mayor would be appointed from the ranks of Sanford's seven city councilors and serve interim for one-year period. On January 8, 2013, Maura A. Herlihy was appointed as Sanford's first mayor.

In 2014, an elected-at-large mayor would take office and serve a three-year initial first term. On November 5, 2013, Thomas Cote was elected as mayor.

Beginning in 2016, the mayoral position will be elected at-large every two years during legislative election cycles.

Sanford is in the western portion of a tract of land purchased in 1661 from Abenaki Chief Fluellin by Major William Phillips, an owner of mills in Saco. First called Phillipstown, it was willed in 1696 by Mrs. Phillips to her former husband's son, Peleg Sanford. Settlement was delayed, however, by hostilities during the French and Indian Wars. In 1724, Norridgewock, an enemy stronghold on the Kennebec River, was destroyed by a Massachusetts militia. Subsequently, the region became less dangerous, and Sanford was first settled in 1739. Incorporated a town in 1768, it was named after Peleg Sanford. Until 1794, Alfred was the town's North Parish.

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