San Francesco della Vigna is a Roman Catholic church in the Sestiere of Castello in Venice, northern Italy.
Along with Santa Maria Gloriosa dei Frari, this is one of two Franciscan churches in Venice. The site, originally a vineyard (Vigna), was donated by Marco Ziani in 1253 for construction of the monastery. A tiny chapel already on the site recalled the spot where an angel supposedly had pronounced Pax tibi Evangelista meus to the shipwrecked apostle St. Mark, patron of Venice.
The first church at the site was a triple-nave Gothic church by Marino da Pisa. A monastery housed the Frati Minori dell'Osservanza, while the Conventuali occupied the Frari across town. By the 16th century, the church building was in need of repair. Two main impulses led to the reconstruction of this church; one was the reform sweeping the order of the Franciscan Observants, and the other was the wishes of Doge Andrea Gritti, whose family palace neighbored the church. In 1534, this Doge laid the foundation stone for the new church. The nave was roofed over by 1554.
The church was designed in sober Renaissance style by Jacopo Sansovino in 1554, with the advice of the Franciscan friar, Fra Francesco Zorzi. Fra Zorzi based the sizing of the various elements on the number three, because of its association with the Trinity: the nave should be nine paces wide and 27 paces long, each side chapel three paces wide. However the white marble façade (1564-1570) was not based on Sansovino's designs, but instead was a product of a Andrea Palladio. It is thought that the patrician Daniele Barbaro lobbied for the commission to be switched from Sansovino to Palladio in 1562, convincing the then Patriarch, Giovanni Grimani.
Palladio addressed the challenge of linking the central nave with the side aisles in the façade in an innovative manner. The Corinthian columns in both the center and the sides are perched on the same high plinth, though the central four columns are taller and wider than the lateral ones. The lateral columns support half-pediments that mimic the angle of the central full pediment. Above the central portal is a hemicircular window, interrupted superiorly by a bracket and subdivided into three parts. The façade contains two large bronze statues of Moses and Saint Paul (1592), actively stepping forward from their shallow niches, sculpted by Tiziano Aspetti.