Coordinates: 41°54′12″N 12°29′35″E / 41.90333°N 12.49306°E
San Caio (English: Saint Caius; sometimes also spelled San Cajo) was an ancient titular church in Rome, possibly dating from as early as the third century. It was demolished in the late nineteenth century.
The church of San Caio was located in the Monti rione of the city, along the ancient Via Pia (now enlarged, and called Via XX Settembre), in the vicinity of Porta Pia. There had been a convent of Barberine nuns (Carmelites of the Incarnation) connected to the church.
After a 1630 reconstruction, the church's facade was characterized by two orders of columns, in back of which there was a campanile. The interior was laid out on the pattern of a Latin cross.
On the first altar to the left when entering the church, there was a painting by Mario Balassi depicting the apparition of the Risen Christ to Mary Magdalene. Another altar in the church held a painting of Saint Bernard contemplating Christ the Savior, with the Blessed Virgin, by Giovanni Battista Camassei. The high altar of the church was decorated with a painting by Giovanni Battista Speranza depicting its patron, Saint Caius, in the act of baptizing.