"Same Script, Different Cast" is a song performed as a duet by American and Canadian R&B singers Whitney Houston and Deborah Cox. Released as a single in 2000, the song features Houston playing the former lover of Cox's current boyfriend. Houston warns Cox of his hurtful ways, though Cox refuses to acknowledge it.

The song incorporates a backing track of Ludwig van Beethoven's Für Elise during the intro. The song was released as a radio-only promo single and hence no video was made. It was a minor hit on Billboard Hot 100, peaking at number 70 while reaching number 14 on Hot R&B/Hip-Hop Songs. The song was also very successful on Hot Dance Club Play, peaking at number 4.

Jim Farber of New York Daily News wrote: "There's a nice tête- ... -tête with label mate Deborah Cox on "Same Script, Different Cast" which amounts to a grownup version of Brandy and Monica's "The Boy Is Mine" JAM! Music's Jane Stevenson preferred this duet: "Toronto's own Deborah Cox fares better with Houston on Same Script, Different Cast than Enrique Iglesias does on the soppy Could I Have This Kiss Forever (Metro Mix)." USA Today's Steve Jones wrote that this collaboration is "most telling." Billboard called this song a special highlight. The Star-Ledger Newark, NJ wrote: "Same Script, Different Cast" isn't much of a song, but gives Houston and duet partner Deborah Cox an opportunity to engage in some thrilling vocal sparring." Sonic.net editor wrote: "Same Script, Different Cast" features plucked harp strings and piano behind a duet with Deborah Cox, the two singers bemoaning that they chose the same loser for a lover"; Barnes & Noble called this song my "man done me wrong" pairing. Essence review called this song special gem in which laides trade sassy lines. Vibe Magazine agreed. Orlando Sentinel editor wrote: "Same Script, Different Cast" plays like a conversation in a Broadway musical. In the song, Houston warns her friend that her current boyfriend eventually will break her heart." Reporter. pl agreed when critics claimed that this is one of the most interesting duets in years. The Baltimore Sun panned the song calling it tepid and bloated. Following Houston's death in 2012, Entertainment Weekly published a list of her 25 best songs and ranked "Same Script, Different Cast" at number 24, commenting "If the boy from the Brandy and Monica duet The Boy Is Mine grew up into a cad, burned Whitney, and took up with Deborah Cox."

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