Saint Regis is a hamlet in the St. Regis Mohawk Reservation in Franklin County, New York, United States. It lies on the NY 37 highway near the Canada–United States border, at the confluence of the St. Regis River with the Saint Lawrence Seaway.
Coordinates: 44°59′50″N 74°39′04″W / 44.99722°N 74.65111°W