Sacrifice (2008) was a professional wrestling pay-per-view (PPV) event produced by the Total Nonstop Action Wrestling (TNA) promotion that took place on May 11, 2008 at the TNA Impact! Zone in Orlando, Florida. It was the fourth event in the Sacrifice chronology and fifth event in the 2008 TNA PPV schedule. Ten professional wrestling matches, two for championships, were featured on the card.

The main event was a Three Way match for the TNA World Heavyweight Championship between then-champion Samoa Joe and challengers Kaz and Scott Steiner. The match was initially promoted as Joe's defense of his title against Kurt Angle and Steiner. However, Angle sustained an injury before the match that removed him from the bout; he was replaced with Kaz. Joe won the match, retaining the championship. The Deuces Wild Tag Team Tournament for the vacant TNA World Tag Team Championship was also held at Sacrifice. The Latin American Xchange (Hernandez and Homicide) defeated Team 3D (Brother Devon and Brother Ray) in the Finals to win the tournament and the championship. TNA featured two matches on the undercard: the TNA Knockouts Makeover Battle Royal for a future TNA Women's Knockout Championship match, and the debut of the TNA TerrorDome to determine who would compete in a future TNA X Division Championship match and take Angle's place in the main event. Gail Kim won the TNA Knockouts Makeover Battle Royal and Kaz won the latter.