SRD5A1

SRD5A1
Identifiers
Aliases	SRD5A1, S5AR 1, steroid 5 alpha-reductase 1
External IDs	MGI: 98400 HomoloGene: 37426 GeneCards: SRD5A1
Gene ontology Molecular function • oxidoreductase activity, acting on the CH-CH group of donors • cholestenone 5-alpha-reductase activity • amide binding • NADPH binding • electron carrier activity • oxidoreductase activity • 3-oxo-5-alpha-steroid 4-dehydrogenase activity Cellular component • cytoplasm • integral component of membrane • organelle membrane • endoplasmic reticulum membrane • cell body fiber • membrane • myelin sheath • intracellular membrane-bounded organelle • neuronal cell body • endoplasmic reticulum • perinuclear region of cytoplasm Biological process • response to fungicide • cell differentiation • pituitary gland development • male gonad development • response to estradiol • response to organic cyclic compound • circadian sleep/wake cycle, REM sleep • androgen metabolic process • thalamus development • lipid metabolic process • cellular response to testosterone stimulus • diterpenoid metabolic process • response to testosterone • cellular response to starvation • cellular response to growth factor stimulus • cellular response to estradiol stimulus • cellular response to organic cyclic compound • sex differentiation • serotonin metabolic process • cellular response to dexamethasone stimulus • response to estrogen • cellular response to epinephrine stimulus • sex determination • response to growth hormone • spinal cord development • hypothalamus development • cerebral cortex development • cellular response to insulin stimulus • urogenital system development • liver development • bone development • hippocampus development • response to muscle activity • response to follicle-stimulating hormone • oxidation-reduction process • response to drug • cellular response to cAMP • steroid metabolic process • androgen biosynthetic process • male genitalia development • female genitalia development • progesterone metabolic process • steroid biosynthetic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6715	78925
Ensembl	ENSG00000145545	ENSMUSG00000021594
UniProt	P18405	Q68FF9
RefSeq (mRNA)	NM_001047 NM_001324322 NM_001324323	NM_175283
RefSeq (protein)	NP_001038 NP_001311251 NP_001311252	NP_780492.2 NP_780492
Location (UCSC)	Chr 5: 6.63 – 6.67 Mb	Chr 13: 69.57 – 69.61 Mb
PubMed search

6715

78925

ENSG00000145545

ENSMUSG00000021594

P18405

Q68FF9

NM_001047
NM_001324322
NM_001324323

NM_175283

NP_001038
NP_001311251
NP_001311252

NP_780492.2
NP_780492

3-oxo-5-alpha-steroid 4-dehydrogenase 1 is an enzyme that in humans is encoded by the SRD5A1 gene.

Steroid 5-alpha-reductase (EC 1.3.99.5) catalyzes the conversion of testosterone into the more potent androgen, dihydrotestosterone (DHT). There are 2 isoforms of the enzyme: SRD5A1 and SRD5A2.

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Wikipedia