SPRED1 gene

SPRED1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3SYX
Identifiers
Aliases	SPRED1, NFLS, PPP1R147, hSpred1, spred-1, sprouty related EVH1 domain containing 1
External IDs	MGI: 2150016 HomoloGene: 24919 GeneCards: SPRED1
Gene location (Human) Chr. Chromosome 15 (human) Band No data available Start 38,252,326 bp End 38,357,249 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band No data available Start 117,121,374 bp End 117,182,279 bp
Gene ontology Molecular function • protein serine/threonine kinase inhibitor activity • phosphatase binding • stem cell factor receptor binding • protein binding • protein kinase binding Cellular component • membrane • plasma membrane • caveola • cytosol • nucleus Biological process • negative regulation of phosphatase activity • inactivation of MAPK activity • negative regulation of peptidyl-threonine phosphorylation • regulation of protein deacetylation • MAPK cascade • multicellular organism development • fibroblast growth factor receptor signaling pathway • regulation of signal transduction • positive regulation of DNA damage response, signal transduction by p53 class mediator • vasculogenesis involved in coronary vascular morphogenesis • negative regulation of cell migration involved in sprouting angiogenesis • negative regulation of MAPK cascade Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	161742	114715
Ensembl	ENSG00000166068	ENSMUSG00000027351
UniProt	Q7Z699	Q924S8
RefSeq (mRNA)	NM_152594	NM_001277256 NM_033524
RefSeq (protein)	NP_689807	NP_001264185 NP_277059
Location (UCSC)	Chr 15: 38.25 – 38.36 Mb	Chr 2: 117.12 – 117.18 Mb
PubMed search

3SYX

161742

114715

ENSG00000166068

ENSMUSG00000027351

Q7Z699

Q924S8

NM_152594

NM_001277256
NM_033524

NP_689807

NP_001264185
NP_277059

Sprouty-related, EVH1 domain-containing protein 1 (Spread-1) is a protein that in humans is encoded by the SPRED1 gene located on chromosome 15q13.2 and has seven coding exons.

Spread-1 is a member of the Sprouty family of proteins and is phosphorylated by tyrosine kinase in response to several growth factors. The encoded protein can act as a homodimer or as a heterodimer with SPRED2 to regulate activation of the MAP kinase cascade.

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Wikipedia