SPOCK1

SPOCK1
Identifiers
Aliases	SPOCK1, SPOCK, TESTICAN, TIC1, sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
External IDs	MGI: 105371 HomoloGene: 80193 GeneCards: SPOCK1
Gene ontology Molecular function • calcium ion binding • cysteine-type endopeptidase inhibitor activity • metalloendopeptidase inhibitor activity • serine-type endopeptidase inhibitor activity Cellular component • cytoplasm • postsynaptic density • proteinaceous extracellular matrix • neuromuscular junction • node of Ranvier • extracellular region • sarcoplasm • extracellular space Biological process • negative regulation of cell-substrate adhesion • neurogenesis • negative regulation of neuron projection development • neuron migration • nervous system development • cell adhesion • regulation of cell growth • central nervous system neuron differentiation • signal transduction • negative regulation of endopeptidase activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6695	20745
Ensembl	ENSG00000152377	ENSMUSG00000056222
UniProt	Q08629	Q62288
RefSeq (mRNA)	NM_004598	NM_001166463 NM_001166464 NM_001166465 NM_001166466 NM_009262
RefSeq (protein)	NP_004589	n/a
Location (UCSC)	Chr 5: 136.98 – 137.6 Mb	Chr 13: 57.42 – 57.91 Mb
PubMed search

6695

20745

ENSG00000152377

ENSMUSG00000056222

Q08629

Q62288

NM_004598

NM_001166463
NM_001166464
NM_001166465
NM_001166466
NM_009262

NP_004589

n/a

Testican-1 is a protein that in humans is encoded by the SPOCK1 gene.

This gene encodes the protein core of a seminal plasma proteoglycan containing chondroitin- and heparan-sulfate chains. The protein's function is under research, though it is from the same family of glycoproteins as SPARC. It is thought its similarity to thyropin-type cysteine protease inhibitors suggests its function may be related to protease inhibition.

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