SNX2

SNX2
Identifiers
Aliases	SNX2, TRG-9, sorting nexin 2
External IDs	MGI: 1915054 HomoloGene: 2332 GeneCards: SNX2
Gene ontology Molecular function • protein homodimerization activity • insulin receptor binding • leptin receptor binding • epidermal growth factor receptor binding • protein binding • phosphatidylinositol binding • protein heterodimerization activity • transferrin receptor binding • lipid binding • cadherin binding Cellular component • cytoplasm • cell projection • early endosome membrane • membrane • retromer, tubulation complex • protein complex • retromer complex • endosome membrane • extracellular exosome • lamellipodium • extrinsic component of membrane • cytosol • lysosome • endosome Biological process • endocytosis • vesicle organization • early endosome to Golgi transport • retrograde transport, endosome to Golgi • protein oligomerization • transport • protein transport • intracellular protein transport • lamellipodium morphogenesis Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6643	67804
Ensembl	ENSG00000205302	ENSMUSG00000034484
UniProt	O60749	Q9CWK8
RefSeq (mRNA)	NM_003100 NM_001278199	NM_026386
RefSeq (protein)	NP_001265128 NP_003091	NP_080662
Location (UCSC)	Chr 5: 122.77 – 122.83 Mb	Chr 18: 53.18 – 53.22 Mb
PubMed search

6643

67804

ENSG00000205302

ENSMUSG00000034484

O60749

Q9CWK8

NM_003100
NM_001278199

NM_026386

NP_001265128
NP_003091

NP_080662

Sorting nexin-2 is a protein that in humans is encoded by the SNX2 gene.

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associates with formin-binding protein 17, but its function is unknown. This protein may form oligomeric complexes with family members.

SNX2 has been shown to interact with FNBP1.

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