SLC5A1 | |||||||
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Identifiers | |||||||
Aliases | SLC5A1, D22S675, NAGT, SGLT1, solute carrier family 5 member 1 | ||||||
External IDs | OMIM: 182380 MGI: 107678 HomoloGene: 55456 GeneCards: SLC5A1 | ||||||
RNA expression pattern | |||||||
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Species | Human | Mouse | |||||
Entrez |
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Ensembl |
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UniProt |
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RefSeq (mRNA) |
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RefSeq (protein) |
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Location (UCSC) | Chr 22: 32.04 – 32.11 Mb | Chr 5: 33.1 – 33.16 Mb | |||||
PubMed search | |||||||
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Sodium/glucose cotransporter 1 also known as solute carrier family 5 member 1 is a protein that in humans is encoded by the SLC5A1 gene.
Glucose transporters are integral membrane proteins that mediate the transport of glucose and structurally related substances across cellular membranes. The role of the sodium-glucose cotransporters is to not only absorb glucose, but to also absorb sodium and to then reabsorb the sodium and glucose from the tubule of the nephron. Two families of glucose transporter have been identified: the facilitated diffusion glucose transporter family (GLUT family), also known as 'uniporters,' and the sodium-dependent glucose transporter family (SGLT family), also known as 'cotransporters' or 'symporters. The SLC5A1 gene encodes a protein that is involved in the active transport of glucose and galactose into eukaryotic and some prokaryotic cells.