SIGLEC12

Identifiers

SIGLEC12, S2V, SIGLECL1, SLG, Siglec-XII, sialic acid binding Ig like lectin 12 (gene/pseudogene)

External IDs

Gene ontology
Molecular function	• carbohydrate binding
Cellular component	• membrane • integral component of membrane
Biological process	• cell adhesion
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


89858


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Ensembl


ENSG00000254521


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UniProt


Q96PQ1


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RefSeq (mRNA)


NM_033329 NM_053003


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RefSeq (protein)


NP_201586.1 NP_443729.1 NP_201586 NP_443729


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Location (UCSC)

Chr 19: 51.49 – 51.5 Mb

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PubMed search

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NP_201586.1
NP_443729.1
NP_201586
NP_443729

n/a

Sialic acid-binding Ig-like lectin 12 is a protein that in humans is encoded by the SIGLEC12 gene.

Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. This gene encodes a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. The encoded protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor. This gene is located in a cluster with other SIGLEC3-like genes on 19q13.4. Alternatively spliced transcript variants encoding distinct isoforms have been described for this gene.

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