SIGLEC10

Identifiers

SIGLEC10, PRO940, SIGLEC-10, SLG2, sialic acid binding Ig like lectin 10

External IDs

MGI: 2443630 HomoloGene: 13228 GeneCards: SIGLEC10

Gene location (Human)

Chr.	Chromosome 19 (human)

Band	No data available	Start	51,410,021 bp
Band	No data available	End	51,417,803 bp

Gene location (Mouse)

Chr.	Chromosome 7 (mouse)

Band	No data available	Start	43,408,204 bp
Band	No data available	End	43,418,358 bp

Gene ontology
Molecular function	• carbohydrate binding
Cellular component	• integral component of membrane • extracellular region • plasma membrane • membrane
Biological process	• cell adhesion • adaptive immune response • immune system process • innate immune response
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


89790


243958

Ensembl


ENSG00000142512


ENSMUSG00000030468

UniProt


Q96LC7


n/a

RefSeq (mRNA)

NM_001171156 NM_001171157 NM_001171158 NM_001171159 NM_001171160
NM_001171161 NM_033130 NM_001322105


NM_172900

RefSeq (protein)

NP_001164627 NP_001164628 NP_001164629 NP_001164630 NP_001164632
NP_001309034 NP_149121


n/a

Location (UCSC)

Chr 19: 51.41 – 51.42 Mb

Chr 19: 43.41 – 43.42 Mb

PubMed search

n/a

NM_001171161
NM_033130
NM_001322105

NM_172900

NP_001309034
NP_149121

n/a

Sialic acid-binding Ig-like lectin 10 is a protein that in humans is encoded by the SIGLEC10 gene. The mouse orthologue is Siglec G.

Like most but not all other Siglecs, Siglec-10 bears an ITIM (Immunoreceptor tyrosine-based inhibitory motif) within its cytoplasmic domain. Siglec-10 is a ligand for CD52, the target of the therapeutic monoclonal antibody Alemtuzumab. It is also reported to bind to Vascular adhesion protein 1 (VAP-1) and to the co-stimulatory molecule CD24 also known as HSA (Heat-stable antigen).

SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).[supplied by OMIM]

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Wikipedia