CD24

CD24
Identifiers
Aliases	CD24, CD24A, CD24 molecule
External IDs	OMIM: 600074 GeneCards: CD24
Gene location (Human) Chr. Chromosome 6 (human) Band No data available Start 106,969,831 bp End 106,975,627 bp
Gene ontology Molecular function • protein tyrosine kinase activator activity • signal transducer activity • protein binding • protein kinase binding Cellular component • membrane • plasma membrane • cell surface • anchored component of external side of plasma membrane • membrane raft • anchored component of membrane • intracellular Biological process • single organismal cell-cell adhesion • response to hypoxia • regulation of MAPK cascade • positive regulation of MAP kinase activity • regulation of cytokine-mediated signaling pathway • positive regulation of cytosolic calcium ion concentration • chemokine receptor transport out of membrane raft • T cell costimulation • regulation of phosphorylation • Wnt signaling pathway • negative regulation of transforming growth factor beta3 production • cell activation • immune response-regulating cell surface receptor signaling pathway • response to estrogen • respiratory burst • intrinsic apoptotic signaling pathway • glomerular parietal epithelial cell differentiation • cell adhesion • glomerular visceral epithelial cell differentiation • cholesterol homeostasis • regulation of epithelial cell differentiation • response to molecule of bacterial origin • cell migration • B cell receptor transport into membrane raft • positive regulation of nephron tubule epithelial cell differentiation • positive regulation of activated T cell proliferation • positive regulation of protein tyrosine kinase activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	100133941	n/a
Ensembl	ENSG00000272398	n/a
UniProt	P25063	n/a
RefSeq (mRNA)	NM_001291737 NM_001291738 NM_001291739 NM_013230	n/a
RefSeq (protein)	NP_001278666 NP_001278667 NP_001278668 NP_037362	n/a
Location (UCSC)	Chr 6: 106.97 – 106.98 Mb	n/a
PubMed search		n/a

100133941

n/a

ENSG00000272398

n/a

P25063

n/a

NM_001291737
NM_001291738
NM_001291739
NM_013230

n/a

NP_001278666
NP_001278667
NP_001278668
NP_037362

n/a

Signal transducer CD24 also known as cluster of differentiation 24 or heat stable antigen CD24 (HSA) is a protein that in humans is encoded by the CD24 gene. CD24 is a cell adhesion molecule.

CD24 is a glycoprotein expressed at the surface of most B lymphocytes and differentiating neuroblasts. This gene encodes a sialoglycoprotein that is expressed on mature granulocytes and in many B cells. The encoded protein is anchored via a glycosyl phosphatidylinositol (GPI) link to the cell surface. The protein also contributes to a wide range of downstream signaling networks and is crucial for neural development. CD24 gene is found on chromosome 6 (6q21) An alignment of this gene's sequence finds genomic locations with similarity on chromosomes 1p36, 3p26, 15q21.3, 20q11.2 and Yq11.222. Whether transcription, and corresponding translation, occurs at each of these other genomic locations needs to be experimentally determined (source: NCBI).

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