SIAH1

SIAH1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2A25, 4C9Z, 4CA1, 4I7B, 4I7C, 4I7D, 4X3G
Identifiers
Aliases	SIAH1, SIAH1A, siah E3 ubiquitin protein ligase 1
External IDs	MGI: 108064 HomoloGene: 20654 GeneCards: SIAH1
Gene ontology Molecular function • metal ion binding • identical protein binding • ubiquitin protein ligase activity • protein binding • zinc ion binding • transferase activity • ubiquitin-protein transferase activity • protein C-terminus binding Cellular component • beta-catenin destruction complex • cytoplasm • nucleus • early endosome • cytosol • plasma membrane Biological process • ubiquitin-dependent protein catabolic process • cell cycle • spermatogenesis • axon guidance • cellular protein metabolic process • multicellular organism development • anatomical structure morphogenesis • positive regulation of intrinsic apoptotic signaling pathway • apoptotic process • protein catabolic process • positive regulation of apoptotic process • nervous system development • protein ubiquitination • cell differentiation • protein polyubiquitination • proteasome-mediated ubiquitin-dependent protein catabolic process • protein destabilization • protein ubiquitination involved in ubiquitin-dependent protein catabolic process • neuron apoptotic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6477	20437
Ensembl	ENSG00000196470	ENSMUSG00000036840
UniProt	Q8IUQ4	P61092
RefSeq (mRNA)	NM_001006610 NM_003031	NM_009172
RefSeq (protein)	NP_001006611 NP_003022	NP_033198
Location (UCSC)	Chr 16: 48.36 – 48.45 Mb	Chr 8: 86.72 – 86.75 Mb
PubMed search

2A25, 4C9Z, 4CA1, 4I7B, 4I7C, 4I7D, 4X3G

6477

20437

ENSG00000196470

ENSMUSG00000036840

Q8IUQ4

P61092

NM_001006610
NM_003031

NM_009172

NP_001006611
NP_003022

NP_033198

E3 ubiquitin-protein ligase SIAH1 is an enzyme that in humans is encoded by the SIAH1 gene.

This gene encodes for a polypeptide structure that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.

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