SGLT1

SLC5A1
Identifiers
Aliases	SLC5A1, D22S675, NAGT, SGLT1, solute carrier family 5 member 1
External IDs	OMIM: 182380 MGI: 107678 HomoloGene: 55456 GeneCards: SLC5A1
Targeted by Drug
canagliflozin anhydrous, dapagliflozin, empagliflozin, sergliflozin etabonate
Gene ontology Molecular function • transporter activity • protein binding • symporter activity • glucose:sodium symporter activity Cellular component • integral component of membrane • membrane • cell-cell junction • plasma membrane • integral component of plasma membrane • brush border membrane • apical plasma membrane • extracellular exosome Biological process • hexose transport • glucose transmembrane transport • sodium ion transport • ion transport • transport • glucose transport • carbohydrate transport • transmembrane transport • intestinal D-glucose absorption Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6523	20537
Ensembl	ENSG00000100170	ENSMUSG00000011034
UniProt	P13866	Q8C3K6
RefSeq (mRNA)	NM_000343 NM_001256314	NM_019810
RefSeq (protein)	NP_000334 NP_001243243	NP_062784.3 NP_062784
Location (UCSC)	Chr 22: 32.04 – 32.11 Mb	Chr 5: 33.1 – 33.16 Mb
PubMed search

6523

20537

ENSG00000100170

ENSMUSG00000011034

P13866

Q8C3K6

NM_000343
NM_001256314

NM_019810

NP_000334
NP_001243243

NP_062784.3
NP_062784

Sodium/glucose cotransporter 1 also known as solute carrier family 5 member 1 is a protein that in humans is encoded by the SLC5A1 gene.

Glucose transporters are integral membrane proteins that mediate the transport of glucose and structurally related substances across cellular membranes. The role of the sodium-glucose cotransporters is to not only absorb glucose, but to also absorb sodium and to then reabsorb the sodium and glucose from the tubule of the nephron. Two families of glucose transporter have been identified: the facilitated diffusion glucose transporter family (GLUT family), also known as 'uniporters,' and the sodium-dependent glucose transporter family (SGLT family), also known as 'cotransporters' or 'symporters. The SLC5A1 gene encodes a protein that is involved in the active transport of glucose and galactose into eukaryotic and some prokaryotic cells.

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Wikipedia