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SGLT-2

SLC5A2
Identifiers
Aliases SLC5A2, SGLT2, solute carrier family 5 member 2
External IDs OMIM: 182381 MGI: 2181411 HomoloGene: 2289 GeneCards: SLC5A2
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003041

NM_133254

RefSeq (protein)

NP_003032

NP_573517.1
NP_573517

Location (UCSC) Chr 16: 31.48 – 31.49 Mb Chr 7: 128.27 – 128.27 Mb
PubMed search

NM_003041

NM_133254

NP_003032

NP_573517.1
NP_573517

The sodium/glucose cotransporter 2 (SGLT2) is a protein that in humans is encoded by the SLC5A2 (solute carrier family 5 (sodium/glucose cotransporter)) gene.

SGLT2 is a member of the sodium glucose cotransporter family which are sodium-dependent glucose transport proteins. SGLT2 is the major cotransporter involved in glucose reabsorption in the kidney.

SGLT2 inhibitors are called gliflozins. They lead to a reduction in blood glucose levels. Therefore, SGLT2 inhibitors have potential use in the treatment of type II diabetes. Gliflozins enhance glycemic control as well as reduce body weight and systolic and diastolic blood pressure. The gliflozins canagliflozin, dapagliflozin, and empagliflozin may lead to euglycemic ketoacidosis. Other side effects of gliflozins include increased risk of (generally mild) urinary tract infections, candidal vulvovaginitis.


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