SCN9A

SCN9A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5EK0
Identifiers
Aliases	SCN9A, ETHA, FEB3B, GEFSP7, HSAN2D, NE-NA, NENA, Nav1.7, PN1, SFNP, sodium voltage-gated channel alpha subunit 9
External IDs	MGI: 107636 HomoloGene: 2237 GeneCards: SCN9A
Gene ontology Molecular function • sodium ion binding • sodium channel activity • voltage-gated ion channel activity • ion channel activity • voltage-gated sodium channel activity Cellular component • voltage-gated sodium channel complex • integral component of membrane • membrane • integral component of plasma membrane • cell projection • plasma membrane Biological process • membrane depolarization during action potential • sodium ion transport • regulation of ion transmembrane transport • post-embryonic development • ion transport • behavioral response to pain • transmembrane transport • sensory perception of pain • inflammatory response • response to toxic substance • neuronal action potential • regulation of postsynaptic membrane potential • sodium ion transmembrane transport • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6335	20274
Ensembl	ENSG00000169432	ENSMUSG00000075316
UniProt	Q15858	Q62205
RefSeq (mRNA)	NM_002977	NM_001290674 NM_001290675 NM_018852
RefSeq (protein)	NP_002968	NP_001277603 NP_001277604
Location (UCSC)	Chr 2: 166.2 – 166.38 Mb	Chr 2: 66.48 – 66.63 Mb
PubMed search

5EK0

6335

20274

ENSG00000169432

ENSMUSG00000075316

Q15858

Q62205

NM_002977

NM_001290674
NM_001290675
NM_018852

NP_002968

NP_001277603
NP_001277604

Na_v1.7 is a sodium ion channel that in humans is encoded by the SCN9A gene. It is usually expressed at high levels in two types of neurons, the nociceptive (pain) neurons at dorsal root ganglion (DRG) and trigeminal ganglion, and sympathetic ganglion neurons, which are part of the autonomic (involuntary) nervous system.

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