SART3

SART3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DO4, 5JJW, 5JJX, 5CTT, 5CTR, 5JPZ, 5CTQ
Identifiers
Aliases	SART3, DSAP1, P100, RP11-13G14, TIP110, p110, p110(nrb), squamous cell carcinoma antigen recognized by T-cells 3
External IDs	MGI: 1858230 HomoloGene: 40977 GeneCards: SART3
Gene ontology Molecular function • nucleotide binding • U6atac snRNA binding • histone binding • U4 snRNA binding • protein binding • nucleic acid binding • ubiquitin-specific protease binding • U6 snRNA binding • RNA binding Cellular component • cytoplasm • Cajal body • nuclear speck • U4/U6 x U5 tri-snRNP complex • nucleoplasm • U4/U6 snRNP • U6atac snRNP • U4atac/U6atac snRNP • nucleus Biological process • mRNA splicing, via spliceosome • nucleosome assembly • RNA processing • spliceosomal tri-snRNP complex assembly • homeostasis of number of cells • positive regulation of histone deubiquitination • hematopoietic stem cell proliferation • mRNA processing • spliceosomal snRNP assembly • cell morphogenesis • RNA splicing • regulation of gene expression Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9733	53890
Ensembl	ENSG00000075856	ENSMUSG00000018974
UniProt	Q15020	Q9JLI8
RefSeq (mRNA)	NM_014706	NM_016926
RefSeq (protein)	NP_055521	NP_058622.1 NP_058622
Location (UCSC)	Chr 12: 108.52 – 108.56 Mb	Chr 5: 113.74 – 113.77 Mb
PubMed search

2DO4, 5JJW, 5JJX, 5CTT, 5CTR, 5JPZ, 5CTQ

9733

53890

ENSG00000075856

ENSMUSG00000018974

Q15020

Q9JLI8

NM_014706

NM_016926

NP_055521

NP_058622.1
NP_058622

Squamous cell carcinoma antigen recognized by T-cells 3 is a protein that in humans is encoded by the SART3 gene.

The protein encoded by this gene is an RNA-binding nuclear protein that is a tumor-rejection antigen. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy. This gene product is found to be an important cellular factor for HIV-1 gene expression and viral replication. It also associates transiently with U6 and U4/U6 snRNPs during the recycling phase of the spliceosome cycle. This encoded protein is thought to be involved in the regulation of mRNA splicing.

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