HLA-A24
| HLA-A24 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| (MHC Class I, A cell surface antigen) | ||||||||||
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| About | ||||||||||
| Protein | transmembrane receptor/ligand | |||||||||
| Structure | αβ heterodimer | |||||||||
| Subunits | HLA-A*24--, β2-microglobulin | |||||||||
| Older names | HL-A9 | |||||||||
| Subtypes | ||||||||||
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| Alleles link-out to IMGT/HLA database at EBI | ||||||||||
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Subtype
|
allele
|
Available structures
|
|---|---|---|
| A24 | *2402 | 2bck |
| A9.3 | *2403 |
| Study population |
Freq. (in %) |
|---|---|
| Taiwan Paiwan | 86.3 |
| Taiwan Tsou | 78.4 |
| Taiwan Rukai | 76.0 |
| Papua New Guinea Goroka | 74.4 |
| PNG Karimui Plateau | 74.4 |
| Taiwan Puyuma | 64.0 |
| Taiwan Ami | 62.8 |
| PNG Wanigela | 62.7 |
| Taiwan Atayal | 61.8 |
| Ecuador Cayapa | 61.4 |
| New Caledonia | 60.7 |
| Venezuela Perja Mtn. Bari | 60.2 |
| USA Alaska Yupik Natives | 58.1 |
| Taiwan Tao | 54.0 |
| PNG Wosera | 51.3 |
| Taiwan Siraya | 47.1 |
| Taiwan Taroko | 44.5 |
| Mexico Chihuahua Tarahuma… | 37.5 |
| USA Arizona Pima | 36.0 |
| Taiwan Pazeh | 33.6 |
| Japan Okinawa Ryukyuan | 33.5 |
| American Samoa | 33.0 |
| Japan (5) | 32.7 |
| Philippines Ivatan | 32.0 |
| PNG New Britain Rabaul | 31.6 |
| N. Mexico Canoncito Navaj… | 30.5 |
| Australia Indig. Yuendumu | 29.8 |
| Australia Indig. Groote E… | 29.3 |
| China Tibetans | 27.2 |
| S. Dakota Lakota Sioux | 26.2 |
| Mexico Mixtec Oaxaca | 24.5 |
| Japan Ainu Hokkaido | 24.0 |
| Venezuela Perija Mtns. Yu… | 23.3 |
| Mexico Zaptotec Oaxaca | 23.1 |
| USA North American Native… | 22.7 |
| Australia Indig. Cape Yor… | 22.3 |
| Ch. Guangdong Meizhou Han | 22.2 |
| Russia Tuva (2) | 21.5 |
| Singapore Chinese Han | 21.5 |
| India North Hindus | 20.2 |
| Mongolia Buriat | 20.0 |
| China Inner Mongolia | 19.6 |
| USA Asian | 18.9 |
| Taiwan Minnan (1) | 18.6 |
| China South Han | 17.2 |
| Georgia Tibilisi Georgian… | 17.1 |
| India Mumbai Marathas | 16.7 |
| Mexico Guadalajara Mestiz… | 16.5 |
| Singapore Riau Malay | 16.5 |
| Croatia | 16.0 |
| India Khandesh Pawra | 16.0 |
| Singapore Javanese Indone… | 16.0 |
| South Africa Natal Tamil | 16.0 |
| India Tamil Nadu Nadar | 15.6 |
| PNG Madang | 15.3 |
| China North Han | 15.2 |
| USA South Texas Hispanics | 15.2 |
| PNG West Schrader Ranges | 14.2 |
| China Guangxi Maonan | 13.4 |
| Mexico Mestizos | 13.4 |
| Georgia Svaneti Svans | 13.1 |
| Romanian | 12.7 |
| Pakistan Burusho | 12.5 |
| USA Hispanic | 12.2 |
| Bulgaria | 11.8 |
| Georgia Tibilisi Kurds | 11.7 |
| India New Delhi | 11.4 |
| Pakistan Sindhi | 10.7 |
| USA Caucasian | 10.7 |
| France South East | 10.6 |
| Pakistan Pathan | 10.2 |
| Cameroon Pygmy Baka | 10.0 |
| Finland | 9.4 |
| Brazil | 8.6 |
| Australia Indig. Kimberly | 8.3 |
| Australia New South Wales | 8.2 |
| Israel Arab Druse | 8.0 |
| Pakistan Baloch | 8.0 |
| Portugal Centre | 8.0 |
| Cameroon Sawa | 7.7 |
| Brazil Terena | 7.5 |
| Ireland South | 6.8 |
| Tunisia | 6.7 |
| Belgium | 6.6 |
| Morocco Berber Nador Meta… | 6.2 |
| Jordan Amman | 5.9 |
| Oman | 5.9 |
| Mexico Mixe Oaxaca | 5.7 |
| Portugal North | 5.4 |
| Sudanese | 5.3 |
| Mexico Sonora Seri | 4.5 |
| Uganda Kampala | 4.3 |
| Thailand | 3.9 |
| Iran Baloch | 3.4 |
| USA African America | 2.8 |
| Kenya | 2.1 |
| Guinea Bissau | 1.5 |
| Czech Republic | 1.0 |
| Kenya Nandi | 1.0 |
| Allele frequencies presented, only | |
HLA-A24 (A24) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α24 subset of HLA-A α-chains. For A24, the alpha, "A", chain are encoded by the HLA-A*24 allele group and the β-chain are encoded by B2M . This group currently is dominated by A*2402. A24 and A*24 are almost synonymous in meaning. A24 is a of the HLA-A9 and it is a sister serotype of HLA-A23.
A*2402 has one of the highest "A" frequencies identified for a number of peoples, including Papua New Guineans, Indigenous Taiwanese (Eastern Tribals), Yupik and Greenland Eskimos. It is common over much of Southeastern Asia. In Eurasia it is least common in Ireland, and A24 is relatively uncommon in Africa except North Africa and Kenya.
There are over 90 known A*24 alleles, 69 code for different isoforms and 7 are nulls. A*2403 can also be detected as A2403 serotype.
A24 has a secondary risk factor for myasthenia gravis,Buerger's disease.
A*2402 is a secondary risk factor, alters type 1 diabetes risk, and allele associated with thymoma-induced myasthenia gravis.
A24-Cw7-B39
A24-Cw10-B60
A24-Cw10-B61
A24-B48
This particular haplotype is common across a fairly wide region, possibly the most widely spread A-Cw-B haplotype in humans. Cw4-B35 has a node within the region once referred to as Thracia/Dacia.
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Wikipedia