Rev-ErbA alpha

NR1D1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1A6Y, 1GA5, 1HLZ, 3N00
Identifiers
Aliases	NR1D1, EAR1, THRA1, THRAL, ear-1, hRev, nuclear receptor subfamily 1 group D member 1
External IDs	OMIM: 602408 MGI: 2444210 HomoloGene: 23324 GeneCards: NR1D1
Targeted by Drug
sr-9009, sr-9011
Gene ontology Molecular function • DNA binding • sequence-specific DNA binding • RNA polymerase II regulatory region sequence-specific DNA binding • transcription corepressor activity • transcription factor activity, sequence-specific DNA binding • zinc ion binding • metal ion binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • steroid hormone receptor activity • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding • RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding • core promoter sequence-specific DNA binding • protein binding • heme binding • transcription regulatory region DNA binding • transcription corepressor binding Cellular component • cytoplasm • cell projection • dendritic spine • nucleoplasm • dendrite • nuclear chromatin • nucleus • nuclear body Biological process • regulation of cholesterol homeostasis • cell differentiation • regulation of insulin secretion involved in cellular response to glucose stimulus • regulation of transcription, DNA-templated • rhythmic process • circadian temperature homeostasis • negative regulation of receptor biosynthetic process • regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter • positive regulation of bile acid biosynthetic process • negative regulation of transcription from RNA polymerase II promoter • circadian regulation of gene expression • regulation of fat cell differentiation • transcription, DNA-templated • positive regulation of transcription, DNA-templated • positive regulation of cholesterol homeostasis • regulation of lipid metabolic process • glycogen biosynthetic process • regulation of circadian rhythm • circadian rhythm • proteasomal protein catabolic process • transcription initiation from RNA polymerase II promoter • response to leptin • negative regulation of transcription, DNA-templated • cellular response to lipopolysaccharide • regulation of type B pancreatic cell proliferation • negative regulation of toll-like receptor 4 signaling pathway • steroid hormone mediated signaling pathway • intracellular receptor signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9572	217166
Ensembl	ENSG00000126368	ENSMUSG00000020889
UniProt	P20393	Q3UV55
RefSeq (mRNA)	NM_021724	NM_145434
RefSeq (protein)	NP_068370	NP_663409.2 NP_663409
Location (UCSC)	Chr 17: 40.09 – 40.1 Mb	Chr 11: 98.77 – 98.78 Mb
PubMed search

1A6Y, 1GA5, 1HLZ, 3N00

9572

217166

ENSG00000126368

ENSMUSG00000020889

P20393

Q3UV55

NM_021724

NM_145434

NP_068370

NP_663409.2
NP_663409

Rev-ErbA alpha also known as NR1D1 (nuclear receptor subfamily 1, group D, member 1), is a protein that in humans is encoded by the NR1D1 gene.

Rev-erbα is member of the Rev-ErbA family of nuclear receptors and is a transcriptional repressor. In mammals, Rev-erbα is highly expressed in the liver, skeletal muscle, adipose tissue, and the brain, participating in the development and circadian regulation of these tissues.

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Wikipedia