Retinal G protein coupled receptor

RGR
Identifiers
Aliases	RGR, RP44, Retinal G protein coupled receptor
External IDs	MGI: 1929473 HomoloGene: 37709 GeneCards: RGR
Gene location (Human) Chr. Chromosome 10 (human) Band n/a Start 84,245,053 bp End 84,259,960 bp
Gene location (Mouse) Chr. Chromosome 14 (mouse) Band n/a Start 37,037,490 bp End 37,048,964 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • G-protein coupled receptor activity • protein binding • photoreceptor activity • signal transducer activity • G-protein coupled photoreceptor activity Cellular component • integral component of membrane • integral component of plasma membrane • membrane Biological process • protein-chromophore linkage • G-protein coupled receptor signaling pathway • signal transduction • visual perception • response to stimulus • phototransduction • detection of visible light Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5995	57811
Ensembl	ENSG00000148604	ENSMUSG00000021804
UniProt	P47804	Q9Z2B3
RefSeq (mRNA)	NM_001012720 NM_001012722 NM_002921	NM_001301692 NM_001301694 NM_021340
RefSeq (protein)	NP_001012738 NP_001012740 NP_002912	NP_001288621 NP_001288623 NP_067315
Location (UCSC)	Chr 10: 84.25 – 84.26 Mb	Chr 10: 37.04 – 37.05 Mb
PubMed search

5995

57811

ENSG00000148604

ENSMUSG00000021804

P47804

Q9Z2B3

NM_001012720
NM_001012722
NM_002921

NM_001301692
NM_001301694
NM_021340

NP_001012738
NP_001012740
NP_002912

NP_001288621
NP_001288623
NP_067315

RPE-retinal G protein-coupled receptor also known as RGR-opsin is a protein that in humans is encoded by the RGR gene.

RGR-opsin is a member of the rhodopsin-like receptor subfamily of GPCR. Like other opsins which bind retinaldehyde, it contains a conserved lysine residue in the seventh transmembrane domain. RGR-opsin preferentially binds all-trans-retinal, which is the dominant form in the dark adapted retina,upon light exposure it is isomerized to 11-cis-retinal. Therefore, RGR-opsin presumably acts as a photoisomerase to convert all-trans-retinal to 11-cis-retinal, similar to retinochrome in invertebrates. 11-cis-retinal is isomerized back within rhodopsin and the iodopsins in the rods and cones of the retina. RGR-opsin is exclusively expressed in tissue close to the rods and cones, the retinal pigment epithelium (RPE) and Müller cells. RGR-opsin may be associated with autosomal recessive and autosomal dominant retinitis pigmentosa (arRP and adRP, respectively). RGR-opsin comes in different isoforms produced by alternative splicing.

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Wikipedia