Rancho Refugio was a 12,147-acre (49.16 km2) Mexican land grant in present-day Santa Cruz County, California given in 1839 by Governor Juan B. Alvarado to María Candida, Jacinta, and María de los Angeles Castro. The grant extended along the Pacific coast from the western city limit of Santa Cruz to Laguna Creek, a border shared with Rancho Arroyo de la Laguna (not far from Davenport).
As Mission Santa Cruz developed following its establishment in 1791, the coastal terrace lands to the north as far as Point Año Nuevo became the mission's main livestock grazing lands. Rancho Arroyo del Matadero (stream of the slaughtering ground ranch) was one of four mission cattle ranches strung along the coast. In 1839, the former ranch lands were granted to the three Castro sisters: María Candida, Jacinta, and María de los Angeles Castro. The three were daughters of José Joaquín Castro (1768–1838), deceased grantee of Rancho San Andrés. Candida Castro married José Antonio Bolcoff in 1822.
José Antonio Bolcoff (1794–1866) was born Osip Volkov in Petropavlovsk-Kamchatsky, Siberia. Working as a fur trader, Bolcoff deserted a Russian ship at Monterey in 1815. He quickly assimilated into the Spanish culture, and was given the Spanish name José Antonio Bolcoff. Bolcoff acted as an interpreter for Governor Pablo Vicente de Solá. In 1822, Bolcoff settled in Branciforte and was alcalde in 1833. In 1833, Bolcoff was granted Rancho San Agustin, which he sold to Joseph Ladd Majors (1806–1868) in 1839. Majors married Bolcoff's sister-in-law, María de los Angeles Castro (1818–1903). Jacinta Castro lived with the Bolcoff family before joining the convent at Monterey. In 1839, Bolcoff replaced Francisco Soto as administrator of Mission Santa Cruz.