Raffaello Petrucci (Siena, 1472 - Rome, 11 December 1522) was a Cardinal and Roman Catholic bishop.
He was born in Siena, circa 1472. He was the son of Giacoppo Petrucci. Since 1494, the year of the Florence Family Doctors' expulsion, he represented the pro-Medici party, advocating for Piero de Medici and his attempts to return home. Between 1495 - 1497, he handled negotiations with the Republic of Siena, aimed at obtaining military support, at a stage where the Republic of Florence had to deal with the rebellion of Pisa (self-proclamating as an independent republic (1494)) and of Montepulciano (1494), and with the campaign by Bartolomeo d'Alviano on behalf of the Republic of Venice, which targeted Casentino (1496–1497).
In 1497, his father died and on August 4, he was elected as bishop of Grosseto. His tenure in Siena was discreet because of is uncle Pandolfo's preponderance, who, after the agreements signed between the Republic of Siena and Florence in 1498, came to take on the role of leading citizen or Primus. Politically, the agreement between the two Republics sanctioned the defeat of both Venetian Niccolo Borghesi and pro-Medicean Raffaele Petrucci. He then moved to Rome to follow Cardinal Giovanni de Medici, remaining bound to him in his years of exile, under the pontificates of Alexander VI and Julius II.
The election of Cardinal Medici to the papacy in March 1513, opened up the possibility of him taking on a more active role in papal policy, especially concerning disagreements between cousins Borghese and Alfonso with Leo X. This led to him claiming the role of Primus and as party leader. In March 1516, with the support of the Pope and Florence, he implemented a coup that brought him to power but, in the wake of greater Church responsibility, was forced to cede control to his nephew, Francesco in 1522.