RYR1

RYR1
Identifiers
Aliases	RYR1, CCO, MHS, MHS1, PPP1R137, RYDR, RYR, RYR-1, SKRR, ryanodine receptor 1
External IDs	MGI: 99659 HomoloGene: 68069 GeneCards: RYR1
Targeted by Drug
adenosine triphosphate, caffeine, suramin, dantrolene, procaine
Gene ontology Molecular function • voltage-gated calcium channel activity • calcium channel activity • calmodulin binding • protease binding • ion channel activity • protein binding • enzyme binding • calcium-release channel activity • ryanodine-sensitive calcium-release channel activity • calcium ion binding • calcium-induced calcium release activity Cellular component • cytoplasm • integral component of membrane • membrane • I band • T-tubule • plasma membrane • integral component of plasma membrane • sarcoplasmic reticulum • junctional sarcoplasmic reticulum membrane • terminal cisterna • smooth endoplasmic reticulum • protein complex • cell cortex • sarcoplasmic reticulum membrane • junctional membrane complex • extracellular exosome Biological process • ossification involved in bone maturation • release of sequestered calcium ion into cytosol • regulation of cardiac conduction • response to hypoxia • muscle contraction • release of sequestered calcium ion into cytosol by sarcoplasmic reticulum • regulation of cytosolic calcium ion concentration • outflow tract morphogenesis • cellular calcium ion homeostasis • ion transport • multicellular organism development • ion transmembrane transport • skeletal muscle fiber development • calcium ion transmembrane transport • transport • response to caffeine • calcium ion transport • skin development • transmembrane transport • cellular response to caffeine Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6261	20190
Ensembl	ENSG00000196218	ENSMUSG00000030592
UniProt	P21817	E9PZQ0
RefSeq (mRNA)	NM_000540 NM_001042723	NM_009109
RefSeq (protein)	NP_000531 NP_001036188	NP_033135.2 NP_033135
Location (UCSC)	Chr 19: 38.43 – 38.59 Mb	Chr 7: 29 – 29.13 Mb
PubMed search

6261

20190

ENSG00000196218

ENSMUSG00000030592

P21817

E9PZQ0

NM_000540
NM_001042723

NM_009109

NP_000531
NP_001036188

NP_033135.2
NP_033135

Ryanodine receptor 1 (RYR-1) also known as skeletal muscle calcium release channel or skeletal muscle-type ryanodine receptor is a protein found primarily in skeletal muscle. In humans, it is encoded by the RYR1 gene.

RYR1 functions as a calcium release channel in the sarcoplasmic reticulum, as well as a connection between the sarcoplasmic reticulum and the transverse tubule. RYR1 is associated with the dihydropyridine receptor (L-type calcium channels) within the sarcolemma of the T-tubule, which opens in response to depolarization, and thus effectively means that the RYR1 channel opens in response to depolarization of the cell.

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