RRM2

RRM2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2UW2, 3OLJ, 3VPM, 3VPN, 3VPO
Identifiers
Aliases	RRM2, R2, RR2, RR2M, ribonucleotide reductase regulatory subunit M2
External IDs	MGI: 98181 HomoloGene: 20277 GeneCards: RRM2
Gene ontology Molecular function • metal ion binding • protein binding • oxidoreductase activity • ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor • ferric iron binding • protein homodimerization activity Cellular component • cytoplasm • cytosol • ribonucleoside-diphosphate reductase complex Biological process • nucleobase-containing small molecule interconversion • protein heterotetramerization • regulation of transcription involved in G1/S transition of mitotic cell cycle • deoxyribonucleotide biosynthetic process • DNA replication • protein oligomerization • oxidation-reduction process • deoxyribonucleotide metabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6241	20135
Ensembl	ENSG00000171848	ENSMUSG00000020649
UniProt	P31350	P11157
RefSeq (mRNA)	NM_001165931 NM_001034	NM_009104
RefSeq (protein)	NP_001025 NP_001159403	NP_033130.1 NP_033130
Location (UCSC)	Chr 2: 10.12 – 10.13 Mb	Chr 12: 24.71 – 24.71 Mb
PubMed search

2UW2, 3OLJ, 3VPM, 3VPN, 3VPO

6241

20135

ENSG00000171848

ENSMUSG00000020649

P31350

P11157

NM_001165931
NM_001034

NM_009104

NP_001025
NP_001159403

NP_033130.1
NP_033130

Ribonucleoside-diphosphate reductase subunit M2, also known as ribonucleotide reductase small subunit, is an enzyme that in humans is encoded by the RRM2 gene.

This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini.

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Wikipedia