ROR2

ROR2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3ZZW, 4GT4
Identifiers
Aliases	ROR2, BDB, BDB1, NTRKR2, receptor tyrosine kinase like orphan receptor 2
External IDs	MGI: 1347521 HomoloGene: 55831 GeneCards: ROR2
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • frizzled binding • metal ion binding • kinase activity • Wnt-protein binding • protein binding • transmembrane receptor protein tyrosine kinase activity • protein tyrosine kinase activity • ATP binding • coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway Cellular component • integral component of membrane • clathrin-coated endocytic vesicle membrane • membrane • plasma membrane • integral component of plasma membrane • cytoplasm • microtubule • cell surface • dendrite • neuronal cell body Biological process • somitogenesis • skeletal system development • cell differentiation • cell fate commitment • SMAD protein signal transduction • phosphorylation • transmembrane receptor protein tyrosine kinase signaling pathway • positive regulation of cell migration • positive regulation of canonical Wnt signaling pathway • regulation of canonical Wnt signaling pathway • embryonic digit morphogenesis • Wnt signaling pathway • BMP signaling pathway • multicellular organism development • positive regulation of transcription, DNA-templated • embryonic genitalia morphogenesis • JNK cascade • protein phosphorylation • Wnt signaling pathway, calcium modulating pathway • inner ear morphogenesis • smoothened signaling pathway • negative regulation of canonical Wnt signaling pathway • cartilage condensation • signal transduction • negative regulation of cell proliferation • peptidyl-tyrosine phosphorylation • Wnt signaling pathway, planar cell polarity pathway • astrocyte development • bone mineralization • male genitalia development • positive regulation of JUN kinase activity • positive regulation of macrophage differentiation • positive regulation of synaptic transmission, glutamatergic • positive regulation of protein kinase C activity • macrophage migration Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4920	26564
Ensembl	ENSG00000169071	ENSMUSG00000021464
UniProt	Q01974	Q9Z138 Q8C3W2
RefSeq (mRNA)	NM_004560 NM_001318204	NM_013846
RefSeq (protein)	NP_001305133 NP_004551	NP_038874
Location (UCSC)	Chr 9: 91.56 – 91.95 Mb	Chr 13: 53.11 – 53.29 Mb
PubMed search

3ZZW, 4GT4

4920

26564

ENSG00000169071

ENSMUSG00000021464

Q01974

Q9Z138
Q8C3W2

NM_004560
NM_001318204

NM_013846

NP_001305133
NP_004551

NP_038874

Tyrosine-protein kinase transmembrane receptor ROR2 also known as neurotrophic tyrosine kinase, receptor-related 2, is a protein that in humans is encoded by the ROR2 gene located on position 9 of the long arm of chromosome 9. This protein is responsible for aspects of bone and cartilage growth. It is involved in Robinow syndrome and autosomal dominant brachydactyly type B. ROR2 is a member of the receptor tyrosine kinase-like orphan receptor (ROR) family.

...
Wikipedia