RNF135

RNF135
Identifiers
Aliases	RNF135, MMFD, REUL, Riplet, L13, ring finger protein 135
External IDs	MGI: 1919206 HomoloGene: 12427 GeneCards: RNF135
Gene location (Human) Chr. Chromosome 17 (human) Band 17q11.2 Start 30,968,785 bp End 30,999,911 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band n/a Start 80,183,851 bp End 80,199,757 bp
Gene ontology Molecular function • ribonucleoprotein complex binding • protein binding • metal ion binding • ubiquitin-protein transferase activity • identical protein binding • transferase activity Cellular component • cytoplasm • cytosol Biological process • positive regulation of interferon-beta production • negative regulation of type I interferon production • innate immune response • regulation of innate immune response • protein ubiquitination • immune system process • protein deubiquitination Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	84282	71956
Ensembl	ENSG00000181481	ENSMUSG00000020707
UniProt	Q8IUD6	Q9CWS1
RefSeq (mRNA)	NM_001184992 NM_032322 NM_197939	NM_028019
RefSeq (protein)	NP_001171921 NP_115698 NP_922921	NP_082295
Location (UCSC)	Chr 17: 30.97 – 31 Mb	Chr 17: 80.18 – 80.2 Mb
PubMed search

84282

71956

ENSG00000181481

ENSMUSG00000020707

Q8IUD6

Q9CWS1

NM_001184992
NM_032322
NM_197939

NM_028019

NP_001171921
NP_115698
NP_922921

NP_082295

RING finger protein 135 is a protein that in humans is encoded by the RNF135 gene.

The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene is located in a chromosomal region known to be frequently deleted in patients with neurofibromatosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

RNF135 has been shown to interact with RARRES3.

...
Wikipedia