RARRES3

RARRES3
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2LKT, 2MY9
Identifiers
Aliases	RARRES3, HRASLS4, HRSL4, PLA1/2-3, RIG1, TIG3, retinoic acid receptor responder 3
External IDs	HomoloGene: 48290 GeneCards: RARRES3
Gene location (Human) Chr. Chromosome 11 (human) Band 11q12.3 Start 63,536,809 bp End 63,546,462 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein binding • hydrolase activity • phospholipase A2 activity • transferase activity, transferring acyl groups Cellular component • integral component of membrane • membrane • cytosol Biological process • lipid catabolic process • lipid metabolic process • negative regulation of cell proliferation • phospholipid metabolic process • phosphatidylethanolamine acyl-chain remodeling Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5920	n/a
Ensembl	ENSG00000133321	n/a
UniProt	Q9UL19	n/a
RefSeq (mRNA)	NM_004585	n/a
RefSeq (protein)	NP_004576	n/a
Location (UCSC)	Chr 11: 63.54 – 63.55 Mb	n/a
PubMed search		n/a

2LKT, 2MY9

5920

n/a

ENSG00000133321

n/a

Q9UL19

n/a

NM_004585

n/a

NP_004576

n/a

Retinoic acid receptor responder protein 3 is a protein that in humans is encoded by the RARRES3 gene.

Retinoids exert biologic effects such as potent growth inhibitory and cell differentiation activities and are used in the treatment of hyperproliferative dermatological diseases. These effects are mediated by specific nuclear receptor proteins that are members of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. RARRES1, RARRES2, and RARRES3 are genes whose expression is upregulated by the synthetic retinoid tazarotene. RARRES3 is thought act as a tumor suppressor or growth regulator.

RARRES3 has been shown to interact with RNF135.

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