RNASEH2A

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
3P56, 3PUF

Identifiers

Aliases

RNASEH2A, AGS4, JUNB, RNASEHI, RNHIA, RNHL, ribonuclease H2 subunit A

External IDs

MGI: 1916974 HomoloGene: 4664 GeneCards: RNASEH2A

Gene location (Human)

Chr.	Chromosome 19 (human)

Band	19p13.13	Start	12,802,063 bp
Band	19p13.13	End	12,813,638 bp

Gene location (Mouse)

Chr.	Chromosome 8 (mouse)

Band	8\|8 C3	Start	84,956,610 bp
Band	8\|8 C3	End	84,969,767 bp

Gene ontology
Molecular function	• RNA binding • nucleic acid binding • nuclease activity • endonuclease activity • RNA-DNA hybrid ribonuclease activity • ribonuclease activity • hydrolase activity • metal ion binding
Cellular component	• ribonuclease H2 complex • nucleus • nucleoplasm • cytosol
Biological process	• mismatch repair • DNA replication • RNA catabolic process • RNA metabolic process • nucleic acid phosphodiester bond hydrolysis • RNA phosphodiester bond hydrolysis, endonucleolytic • RNA phosphodiester bond hydrolysis • DNA replication, removal of RNA primer
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


10535


69724

Ensembl


ENSG00000104889


ENSMUSG00000052926

UniProt


O75792


O75792 Q9CWY8

RefSeq (mRNA)


NM_006397


NM_027187

RefSeq (protein)


NP_006388


NP_006388 NP_081463

Location (UCSC)

Chr 19: 12.8 – 12.81 Mb

Chr 19: 84.96 – 84.97 Mb

PubMed search

Ribonuclease H2 subunit A, also known as RNase H2 subunit A, is an enzyme that in humans is encoded by the RNASEH2A gene.

The protein encoded by this gene is a component of the heterotrimeric type II ribonuclease H enzyme (RNaseH2). The other two subunits are the non-catalytic RNASEH2B and RNASEH2C. RNaseH2 is the major source of ribonuclease H activity in mammalian cells and endonucleolytically cleaves ribonucleotides. It is predicted to remove Okazaki fragment RNA primers during lagging strand DNA synthesis and to excise single ribonucleotides from DNA-DNA duplexes.

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