RET proto-oncogene

RET

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2IVS, 2IVT, 2IVU, 2IVV, 2X2K, 2X2L, 2X2M, 2X2U, 4CKI, 4CKJ, 4UX8, 5AMN

Identifiers

Aliases

RET, Ret, PTC, RET51, RET9, c-Ret, CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, RET-ELE1, ret proto-oncogene

External IDs

MGI: 97902 HomoloGene: 7517 GeneCards: RET

Targeted by Drug

linifanib, ponatinib, sorafenib, sunitinib, vandetanib

Gene ontology
Molecular function	• transferase activity • nucleotide binding • calcium ion binding • protein kinase activity • kinase activity • protein binding • protein tyrosine kinase activity • ATP binding • receptor activity • Ras guanyl-nucleotide exchange factor activity • transmembrane receptor protein tyrosine kinase activity
Cellular component	• integral component of membrane • endosome • intracellular membrane-bounded organelle • membrane • receptor complex • integral component of plasma membrane • axon • neuronal cell body • dendrite • early endosome • membrane raft • endosome membrane • plasma membrane • cytosol • cytoplasm
Biological process	• cellular response to retinoic acid • ureteric bud development • embryonic epithelial tube formation • membrane protein proteolysis • phosphorylation • transmembrane receptor protein tyrosine kinase signaling pathway • positive regulation of cell migration • neuron cell-cell adhesion • nervous system development • neuron maturation • positive regulation of metanephric glomerulus development • positive regulation of transcription, DNA-templated • regulation of axonogenesis • protein phosphorylation • enteric nervous system development • positive regulation of extrinsic apoptotic signaling pathway in absence of ligand • regulation of cell adhesion • lymphocyte migration into lymphoid organs • cell adhesion • positive regulation of gene expression • ureter maturation • response to pain • retina development in camera-type eye • neural crest cell migration • neuron differentiation • positive regulation of cell size • positive regulation of neuron projection development • posterior midgut development • positive regulation of cell adhesion mediated by integrin • innervation • positive regulation of neuron maturation • activation of cysteine-type endopeptidase activity involved in apoptotic process • response to drug • signal transduction • positive regulation of serine phosphorylation of STAT3 protein • homophilic cell adhesion via plasma membrane adhesion molecules • Peyer's patch morphogenesis • positive regulation of GTPase activity • peptidyl-tyrosine phosphorylation • MAPK cascade • axon guidance
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


5979


19713

Ensembl


ENSG00000165731


ENSMUSG00000030110

UniProt


P07949


P35546

RefSeq (mRNA)


NM_000323 NM_020629 NM_020630 NM_020975


NM_001080780 NM_009050

RefSeq (protein)


NP_065681 NP_066124 NP_066124.1


NP_001074249.1 NP_033076.2

Location (UCSC)

Chr 10: 43.08 – 43.13 Mb

Chr 6: 118.15 – 118.2 Mb

PubMed search

2IVS, 2IVT, 2IVU, 2IVV, 2X2K, 2X2L, 2X2M, 2X2U, 4CKI, 4CKJ, 4UX8, 5AMN

NM_000323
NM_020629
NM_020630
NM_020975

NM_001080780
NM_009050

...
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