RENBP

RENBP
Identifiers
Aliases	RENBP, RBP, RNBP, renin binding protein
External IDs	MGI: 105940 HomoloGene: 2184 GeneCards: RENBP
Gene ontology Molecular function • enzyme inhibitor activity • endopeptidase inhibitor activity • catalytic activity • isomerase activity • ATP binding • protein homodimerization activity • purine nucleotide binding • N-acylglucosamine 2-epimerase activity Cellular component • extracellular exosome • cytosol Biological process • N-acetylmannosamine metabolic process • regulation of blood pressure • N-acetylneuraminate catabolic process • negative regulation of catalytic activity • negative regulation of endopeptidase activity • N-acetylglucosamine metabolic process • UDP-N-acetylglucosamine biosynthetic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5973	19703
Ensembl	ENSG00000102032	ENSMUSG00000031387
UniProt	P51606	P82343
RefSeq (mRNA)	NM_002910	NM_001164704 NM_023132
RefSeq (protein)	NP_002901	NP_001158176.1 NP_075621.3 NP_001158176 NP_075621
Location (UCSC)	Chr X: 153.94 – 153.94 Mb	Chr X: 73.92 – 73.93 Mb
PubMed search

5973

19703

ENSG00000102032

ENSMUSG00000031387

P51606

P82343

NM_002910

NM_001164704
NM_023132

NP_002901

NP_001158176.1
NP_075621.3
NP_001158176
NP_075621

N-acylglucosamine 2-epimerase is an enzyme that in humans is encoded by the RENBP gene.

The gene product inhibits renin activity by forming a dimer with renin, a complex known as high molecular weight renin. The encoded protein contains a leucine zipper domain, which is essential for its dimerization with renin. The gene product can catalyze the interconversion of N-acetylglucosamine to N-acetylmannosamine, indicating that it is a GlcNAc 2-epimerase. Transcript variants utilizing alternative promoters have been described in the literature.

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