Renin

REN
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4XX4, 1BBS, 1BIL, 1BIM, 1HRN, 1RNE, 2BKS, 2BKT, 2FS4, 2G1N, 2G1O, 2G1R, 2G1S, 2G1Y, 2G20, 2G21, 2G22, 2G24, 2G26, 2G27, 2I4Q, 2IKO, 2IKU, 2IL2, 2REN, 2V0Z, 2V10, 2V11, 2V12, 2V13, 2V16, 2X0B, 3D91, 3G6Z, 3G70, 3G72, 3GW5, 3K1W, 3KM4, 3O9L, 3OAD, 3OAG, 3OOT, 3OQF, 3OQK, 3OWN, 3Q3T, 3Q4B, 3Q5H, 3SFC, 3VCM, 3VSW, 3VSX, 3VUC, 3VYD, 3VYE, 3VYF, 4AMT, 4GJ5, 4GJ6, 4GJ7, 4GJ8, 4GJ9, 4GJA, 4GJB, 4GJC, 4GJD, 4PYV, 4Q1N, 4RYC, 4RYG, 4RZ1, 4S1G, 4XX3
Identifiers
Aliases	REN, HNFJ2, renin
External IDs	OMIM: 179820 MGI: 97898 HomoloGene: 20151 GeneCards: REN
Targeted by Drug
aliskiren
Gene ontology Molecular function • insulin-like growth factor receptor binding • aspartic-type endopeptidase activity • endopeptidase activity • peptidase activity • receptor binding • hydrolase activity Cellular component • cytoplasm • membrane • plasma membrane • intracellular • extracellular region • extracellular space Biological process • response to immobilization stress • regulation of blood volume by renin-angiotensin • male gonad development • regulation of MAPK cascade • kidney development • renin-angiotensin regulation of aldosterone production • cell maturation • beta-amyloid metabolic process • response to organic substance • angiotensin maturation • proteolysis • mesonephros development • regulation of blood pressure • response to lipopolysaccharide • cellular response to drug • protein catabolic process • drinking behavior • hormone-mediated signaling pathway • response to cGMP • response to cAMP • response to drug Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5972	19701
Ensembl	ENSG00000143839	ENSMUSG00000070645
UniProt	P00797	P06281
RefSeq (mRNA)	NM_000537	NM_031192
RefSeq (protein)	NP_000528	NP_112469.1 NP_112469
Location (UCSC)	Chr 1: 204.15 – 204.19 Mb	Chr 1: 133.35 – 133.36 Mb
PubMed search

renin
Identifiers
EC number	3.4.23.15
CAS number	9015-94-5
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

Search
PMC	articles
PubMed	articles
NCBI	proteins

4XX4, 1BBS, 1BIL, 1BIM, 1HRN, 1RNE, 2BKS, 2BKT, 2FS4, 2G1N, 2G1O, 2G1R, 2G1S, 2G1Y, 2G20, 2G21, 2G22, 2G24, 2G26, 2G27, 2I4Q, 2IKO, 2IKU, 2IL2, 2REN, 2V0Z, 2V10, 2V11, 2V12, 2V13, 2V16, 2X0B, 3D91, 3G6Z, 3G70, 3G72, 3GW5, 3K1W, 3KM4, 3O9L, 3OAD, 3OAG, 3OOT, 3OQF, 3OQK, 3OWN, 3Q3T, 3Q4B, 3Q5H, 3SFC, 3VCM, 3VSW, 3VSX, 3VUC, 3VYD, 3VYE, 3VYF, 4AMT, 4GJ5, 4GJ6, 4GJ7, 4GJ8, 4GJ9, 4GJA, 4GJB, 4GJC, 4GJD, 4PYV, 4Q1N, 4RYC, 4RYG, 4RZ1, 4S1G, 4XX3

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