RAPGEF3

RAPGEF3
Identifiers
Aliases	RAPGEF3, CAMP-GEFI, EPAC, EPAC1, HSU79275, bcm910, Rap guanine nucleotide exchange factor 3
External IDs	MGI: 2441741 HomoloGene: 21231 GeneCards: RAPGEF3
Gene ontology Molecular function • nucleotide binding • protein domain specific binding • cAMP binding • protein binding • Rap guanyl-nucleotide exchange factor activity • guanyl-nucleotide exchange factor activity Cellular component • filopodium • microvillus • cortical actin cytoskeleton • extracellular exosome • endomembrane system • lamellipodium • intracellular • membrane • plasma membrane Biological process • establishment of endothelial barrier • regulation of actin cytoskeleton reorganization • intracellular signal transduction • regulation of insulin secretion • small GTPase mediated signal transduction • Rap protein signal transduction • positive regulation of syncytium formation by plasma membrane fusion • positive regulation of cAMP catabolic process • regulation of histone H3-K9 acetylation • positive regulation of peptidyl-serine phosphorylation • positive regulation of angiogenesis • positive regulation of protein acetylation • positive regulation of protein export from nucleus • positive regulation of GTPase activity • angiogenesis • cell proliferation • cAMP-mediated signaling • positive regulation of stress fiber assembly • signal transduction • cellular response to cAMP • negative regulation of syncytium formation by plasma membrane fusion Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10411	223864
Ensembl	ENSG00000079337	ENSMUSG00000022469
UniProt	O95398	Q8VCC8
RefSeq (mRNA)	NM_001098531 NM_001098532 NM_006105	NM_001177810 NM_001177811 NM_144850
RefSeq (protein)	NP_001092001 NP_001092002 NP_006096	NP_001171281.1 NP_001171282.1 NP_659099.2 NP_001171281 NP_001171282 NP_659099
Location (UCSC)	Chr 12: 47.73 – 47.77 Mb	Chr 15: 97.74 – 97.77 Mb
PubMed search

10411

223864

ENSG00000079337

ENSMUSG00000022469

O95398

Q8VCC8

NM_001098531
NM_001098532
NM_006105

NM_001177810
NM_001177811
NM_144850

NP_001092001
NP_001092002
NP_006096

NP_659099

Rap guanine nucleotide exchange factor 3 also known as exchange factor directly activated by cAMP 1 (EPAC1) or cAMP-regulated guanine nucleotide exchange factor I (cAMP-GEFI) is a protein that in humans is encoded by the RAPGEF3 gene.

As the name suggests, EPAC proteins (EPAC1 and EPAC2) are a family of intracellular sensors for cAMP, and function as nucleotide exchange factors for the Rap subfamily of RAS-like small GTPases.

...
Wikipedia