RAG2

RAG2
Identifiers
Aliases	RAG2, RAG-2, recombination activating gene 2
External IDs	MGI: 97849 HomoloGene: 7507 GeneCards: RAG2
Gene ontology Molecular function • DNA binding • ubiquitin protein ligase activity • zinc ion binding • chromatin binding • phosphatidylinositol-3,5-bisphosphate binding • metal ion binding • phosphatidylinositol-3,4-bisphosphate binding • methylated histone binding • phosphatidylinositol binding • phosphatidylinositol-4,5-bisphosphate binding • phosphatidylinositol-3,4,5-trisphosphate binding Cellular component • nucleoplasm • nucleus Biological process • DNA recombination • B cell homeostatic proliferation • T cell differentiation in thymus • positive regulation of organ growth • T cell differentiation • B cell lineage commitment • protein ubiquitination • V(D)J recombination • pre-B cell allelic exclusion • B cell differentiation • T cell lineage commitment • covalent chromatin modification • defense response to bacterium Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5897	19374
Ensembl	ENSG00000175097	ENSMUSG00000032864
UniProt	P55895	P21784
RefSeq (mRNA)	NM_000536 NM_001243785 NM_001243786	NM_009020
RefSeq (protein)	NP_000527 NP_001230714 NP_001230715	NP_033046.1 NP_033046
Location (UCSC)	Chr 11: 36.58 – 36.6 Mb	Chr 2: 101.62 – 101.63 Mb
PubMed search

5897

19374

ENSG00000175097

ENSMUSG00000032864

P55895

P21784

NM_000536
NM_001243785
NM_001243786

NM_009020

NP_000527
NP_001230714
NP_001230715

NP_033046.1
NP_033046

Recombination activating gene 2 also known as RAG-2 is a protein that in humans is encoded by the RAG2 gene.

This gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4.

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