RAG1

RAG1
Identifiers
Aliases	RAG1, RAG-1, RNF74, recombination activating gene 1
External IDs	MGI: 97848 HomoloGene: 387 GeneCards: RAG1
Gene ontology Molecular function • DNA binding • sequence-specific DNA binding • protein homodimerization activity • ubiquitin protein ligase activity • histone binding • zinc ion binding • metal ion binding • ubiquitin-protein transferase activity • protein binding • catalytic activity • nucleic acid binding • nuclease activity • endonuclease activity • hydrolase activity • transferase activity Cellular component • nucleoplasm • nucleus Biological process • positive regulation of T cell differentiation • histone monoubiquitination • DNA recombination • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • adaptive immune response • T cell differentiation in thymus • nucleic acid phosphodiester bond hydrolysis • thymus development • negative regulation of thymocyte apoptotic process • T cell homeostasis • negative regulation of T cell apoptotic process • immune response • V(D)J recombination • pre-B cell allelic exclusion • B cell differentiation • metabolic process • regulation of T cell differentiation • protein autoubiquitination • covalent chromatin modification Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5896	19373
Ensembl	ENSG00000166349	ENSMUSG00000061311
UniProt	P15918	P15919
RefSeq (mRNA)	NM_000448	NM_009019
RefSeq (protein)	NP_000439	NP_033045.2 NP_033045
Location (UCSC)	Chr 11: 36.51 – 36.59 Mb	Chr 2: 101.64 – 101.65 Mb
PubMed search

5896

19373

ENSG00000166349

ENSMUSG00000061311

P15918

P15919

NM_000448

NM_009019

NP_000439

NP_033045.2
NP_033045

Recombination activating gene 1 also known as RAG-1 is a protein that in humans is encoded by the RAG1 gene.

The protein encoded by this gene is involved in activation of immunoglobulin V-D-J recombination. The encoded protein is involved in recognition of the DNA substrate, but stable binding and cleavage activity also requires RAG2. The RAG-1/2 complex recognizes the Recombination Signal Sequence (RSS) that flank the V, D and J regions in the gene that codes for the constant region of both the heavy chain and light chain in an antibody. The complex binds to the Recombination Signal Sequences and nicks the DNA. This leads to the removal of the RSS and the eventual binding of the V D and J sequences. Defects in this gene can be the cause of several diseases.

...
Wikipedia