RAB7B

Identifiers

RAB7B, RAB7, member RAS oncogene family

External IDs

MGI: 2442295 HomoloGene: 64833 GeneCards: RAB7B

Gene location (Human)

Chr.	Chromosome 1 (human)

Band	1q32.1	Start	205,976,740 bp
Band	1q32.1	End	206,003,461 bp

Gene location (Mouse)

Chr.	Chromosome 1 (mouse)

Band	n/a	Start	131,688,695 bp
Band	n/a	End	131,715,439 bp

Gene ontology
Molecular function	• nucleotide binding • GTP binding • GTPase activity
Cellular component	• endosome • late endosome • Golgi apparatus • trans-Golgi network • lysosome • phagocytic vesicle membrane • phagocytic vesicle • membrane • cytoplasmic vesicle • late endosome membrane
Biological process	• protein transport • negative regulation of toll-like receptor 9 signaling pathway • late endosome to Golgi transport • positive regulation of NF-kappaB transcription factor activity • positive regulation of megakaryocyte differentiation • negative regulation of toll-like receptor 4 signaling pathway • positive regulation of interleukin-6 production • membrane organization • transport
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


338382


226421

Ensembl


ENSG00000276600


ENSMUSG00000052688

UniProt


Q96AH8


Q8VEA8

RefSeq (mRNA)


NM_001164522 NM_001304839 NM_177403


NM_145509 NM_001311096

RefSeq (protein)


NP_001157994 NP_001291768 NP_796377


NP_001298025 NP_663484

Location (UCSC)

Chr 1: 205.98 – 206 Mb

Chr 1: 131.69 – 131.72 Mb

PubMed search

NM_001164522
NM_001304839
NM_177403

NM_145509
NM_001311096

NP_001157994
NP_001291768
NP_796377

NP_001298025
NP_663484

Ras-related protein Rab-7b is a protein that in humans is encoded by the RAB7B gene.

Rab7 is a small GTPase that plays a role in the transport and degradation of proteins in endosomes and lysosomes in mammalian cells. Rab7b, is localized to lysosome-associated compartments and is selectively expressed in monocytic cells. By promoting the degradation of toll-like receptor 4, RAB7B can negatively regulate the inflammatory activation of macrophages.

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Wikipedia