TLR 4

TLR4

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
4G8A, 2Z62, 2Z63, 2Z65, 2Z66, 3FXI, 3UL7, 3UL8, 3UL9, 3ULA

Identifiers

Aliases

TLR4, ARMD10, CD284, TLR-4, TOLL, toll like receptor 4

External IDs

OMIM: 603030 MGI: 96824 HomoloGene: 41317 GeneCards: TLR4

Gene ontology
Molecular function	• lipopolysaccharide receptor activity • lipopolysaccharide binding • protein binding • transmembrane signaling receptor activity • receptor activity
Cellular component	• cytoplasm • membrane • perinuclear region of cytoplasm • cell surface • integral component of membrane • plasma membrane • endosome membrane • intrinsic component of plasma membrane • integral component of plasma membrane • lipopolysaccharide receptor complex • external side of plasma membrane
Biological process	• positive regulation of MHC class II biosynthetic process • positive regulation of JNK cascade • TRIF-dependent toll-like receptor signaling pathway • positive regulation of interleukin-12 biosynthetic process • cellular response to mechanical stimulus • positive regulation of interleukin-8 production • positive regulation of ERK1 and ERK2 cascade • T-helper 1 type immune response • interferon-gamma production • positive regulation of platelet activation • positive regulation of interleukin-1 production • positive regulation of stress-activated MAPK cascade • positive regulation of NLRP3 inflammasome complex assembly • positive regulation of interleukin-12 production • positive regulation of interferon-alpha production • regulation of cytokine secretion • positive regulation of interferon-beta biosynthetic process • I-kappaB phosphorylation • positive regulation of nitric-oxide synthase biosynthetic process • interleukin-1 beta secretion • positive regulation of B cell proliferation • defense response to bacterium • positive regulation of interleukin-6 production • activation of innate immune response • positive regulation of tumor necrosis factor production • positive regulation of interleukin-8 biosynthetic process • negative regulation of tumor necrosis factor production • innate immune response • negative regulation of interleukin-17 production • I-kappaB kinase/NF-kappaB signaling • positive regulation of interferon-beta production • positive regulation of inflammatory response • toll-like receptor 4 signaling pathway • positive regulation of macrophage cytokine production • positive regulation of tumor necrosis factor biosynthetic process • positive regulation of interleukin-10 production • immune system process • astrocyte development • intestinal epithelial structure maintenance • positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway • response to lipopolysaccharide • activation of MAPK activity • cellular response to lipoteichoic acid • positive regulation of NF-kappaB transcription factor activity • immune response • negative regulation of interleukin-23 production • regulation of inflammatory response • positive regulation of chemokine production • lipopolysaccharide-mediated signaling pathway • detection of fungus • positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway • negative regulation of interferon-gamma production • response to bacterium • negative regulation of osteoclast differentiation • B cell proliferation involved in immune response • positive regulation of nitric oxide biosynthetic process • negative regulation of interleukin-6 production • positive regulation of interferon-gamma production • nitric oxide production involved in inflammatory response • MyD88-dependent toll-like receptor signaling pathway • regulation of dendritic cell cytokine production • positive regulation of gene expression • negative regulation of ERK1 and ERK2 cascade • positive regulation of I-kappaB kinase/NF-kappaB signaling • macrophage activation • positive regulation of NF-kappaB import into nucleus • detection of lipopolysaccharide • cellular response to lipopolysaccharide • positive regulation of lymphocyte proliferation • positive regulation of transcription from RNA polymerase II promoter • MyD88-independent toll-like receptor signaling pathway • signal transduction • inflammatory response • defense response to Gram-negative bacterium • toll-like receptor signaling pathway • necroptotic process • apoptotic signaling pathway • negative regulation of MyD88-independent toll-like receptor signaling pathway
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


7099


21898

Ensembl


ENSG00000136869


ENSMUSG00000039005

UniProt


O00206


Q9QUK6

RefSeq (mRNA)


NM_138557 NM_003266 NM_138554 NM_138556


NM_021297

RefSeq (protein)


NP_003257 NP_612564 NP_612567


NP_067272.1 NP_067272

Location (UCSC)

Chr 9: 117.7 – 117.72 Mb

Chr 4: 66.83 – 66.93 Mb

PubMed search

4G8A, 2Z62, 2Z63, 2Z65, 2Z66, 3FXI, 3UL7, 3UL8, 3UL9, 3ULA

NM_138557
NM_003266
NM_138554
NM_138556

NM_021297

NP_003257
NP_612564
NP_612567

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