RAB11FIP5

RAB11FIP5
Identifiers
Aliases	RAB11FIP5, GAF1, RIP11, pp75, RAB11 family interacting protein 5
External IDs	MGI: 1098586 HomoloGene: 9158 GeneCards: RAB11FIP5
Gene location (Human) Chr. Chromosome 2 (human) Band No data available Start 73,073,382 bp End 73,156,721 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band No data available Start 85,334,962 bp End 85,374,634 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • Rab GTPase binding • protein binding • gamma-tubulin binding Cellular component • cytoplasm • endosome • Golgi apparatus • early endosome membrane • intracellular membrane-bounded organelle • membrane • mitochondrial membrane • Golgi membrane • transport vesicle membrane • microtubule organizing center • mitochondrial outer membrane • recycling endosome membrane • mitochondrion • cytoplasmic vesicle • early endosome • secretory granule • recycling endosome Biological process • regulation of protein localization to cell surface • cellular response to acidic pH • protein transport • negative regulation of adiponectin secretion • insulin secretion involved in cellular response to glucose stimulus • regulated exocytosis • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	26056	52055
Ensembl	ENSG00000135631	ENSMUSG00000051343
UniProt	Q9BXF6	Q8R361
RefSeq (mRNA)	NM_015470	NM_001003955 NM_177466
RefSeq (protein)	NP_056285	NP_001003955 NP_803417
Location (UCSC)	Chr 2: 73.07 – 73.16 Mb	Chr 2: 85.33 – 85.37 Mb
PubMed search

26056

52055

ENSG00000135631

ENSMUSG00000051343

Q9BXF6

Q8R361

NM_015470

NM_001003955
NM_177466

NP_056285

NP_001003955
NP_803417

Rab11 family-interacting protein 5 is a protein that in humans is encoded by the RAB11FIP5 gene.

RAB11FIP5 has been shown to interact with RAB11A and RAB25.

Rab11FIP5 is one of the many proteins that have been shown to interact with the Rab11 protein. Rab GTPases, such as Rab11, are enzymes that are involved in vesicular trafficking. Rab11 specifically plays a key role in endocytic trafficking and recycling through guiding early endosomes to endosome recycling complexes. Rab11FIP5, like most other Rab11FIP proteins, interacts with Rab11 by serving as an adaptor protein. This leads to downstream changes with regards to which proteins can interact. This is a result of the various Rab11FIP proteins that each have different binding partners. This process allows for the coordination and organization of endosomal transport and ultimately gives Rab11 its versatile function in the cell. It is believed that Rab11 recruits specific Rab11FIP proteins to the surface of vesicles in order to determine how the vesicle will behave.

...
Wikipedia