Route 2 was a previous number used for a major highway in the Canadian province of Quebec. The highway stretched from the Ontario border at Rivière-Beaudette to the New Brunswick border southeast of Dégelis. The highway was part of a de facto interprovincial Route 2 that stretched from Windsor, Ontario to Halifax, Nova Scotia, connecting Ontario Highway 2 to New Brunswick Route 2, and further to Nova Scotia, connecting with Trunk 2.
In the mid-1970s, as part of Quebec's renumbering scheme, Route 2 was replaced by the following routes: