QARS

QARS
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 4R3Z, 4YE9, 4YE6, 4YE8
Identifiers
Aliases	QARS, GLNRS, MSCCA, PRO2195, glutaminyl-tRNA synthetase
External IDs	HomoloGene: 3704 GeneCards: QARS
Gene location (Human) Chr. Chromosome 3 (human) Band 3p21.31 Start 49,095,932 bp End 49,105,135 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • aminoacyl-tRNA ligase activity • nucleotide binding • ligase activity • protein binding • ATP binding • protein kinase inhibitor activity • protein kinase binding • glutamine-tRNA ligase activity Cellular component • cytoplasm • mitochondrial matrix • protein complex • aminoacyl-tRNA synthetase multienzyme complex • cytosol Biological process • brain development • glutaminyl-tRNA aminoacylation • tRNA aminoacylation • translation • tRNA aminoacylation for protein translation • negative regulation of protein kinase activity • negative regulation of stress-activated MAPK cascade • negative regulation of transcription, DNA-templated • negative regulation of apoptotic signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5859	n/a
Ensembl	ENSG00000172053	n/a
UniProt	P47897	n/a
RefSeq (mRNA)	NM_001272073 NM_005051	n/a
RefSeq (protein)	NP_001259002 NP_005042	n/a
Location (UCSC)	Chr 3: 49.1 – 49.11 Mb	n/a
PubMed search		n/a

4R3Z, 4YE9, 4YE6, 4YE8

5859

n/a

ENSG00000172053

n/a

P47897

n/a

NM_001272073
NM_005051

n/a

NP_001259002
NP_005042

n/a

Glutaminyl-tRNA synthetase is an enzyme that in humans is encoded by the QARS gene.

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. In metazoans, 9 aminoacyl-tRNA synthetases specific for glutamine (gln), glutamic acid (glu), and 7 other amino acids are associated within a multienzyme complex. Although present in eukaryotes, glutaminyl-tRNA synthetase (QARS) is absent from many prokaryotes, mitochondria, and chloroplasts, in which Gln-tRNA(Gln) is formed by transamidation of the misacylated Glu-tRNA(Gln). Glutaminyl-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family. Almost all eukaryotic GlnRS enzymes possess a YqeY domain at the N-terminus, which affects affinity for the tRNA; in some bacterial species, such as Deinococcus radiodurans, YqeY is present as a C-terminal domain with similar function.

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