Purine nucleoside phosphorylase

purine-nucleoside phosphorylase
purine-nucleoside phosphorylase. PDB 1rct.
Identifiers
EC number	2.4.2.1
CAS number	9030-21-1
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

PNP
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1M73, 1PF7, 1PWY, 1RCT, 1RFG, 1RR6, 1RSZ, 1RT9, 1ULA, 1ULB, 1V2H, 1V3Q, 1V41, 1V45, 1YRY, 2A0W, 2A0X, 2A0Y, 2OC4, 2OC9, 2ON6, 2Q7O, 3BGS, 3D1V, 3GB9, 3GGS, 3INY, 3K8O, 3K8Q, 3PHB, 4EAR, 4EB8, 4ECE, 4GKA
Identifiers
Aliases	PNP, NP, PRO1837, PUNP, purine nucleoside phosphorylase
External IDs	OMIM: 164050 MGI: 3712328 HomoloGene: 227 GeneCards: PNP
Targeted by Drug
forodesine
Gene ontology Molecular function • transferase activity • phosphate ion binding • nucleoside binding • transferase activity, transferring glycosyl groups • purine-nucleoside phosphorylase activity • purine nucleobase binding • catalytic activity • drug binding • transferase activity, transferring pentosyl groups Cellular component • cytoplasm • cytosol • intracellular • extracellular exosome • cytoskeleton • nucleus • extracellular region • secretory granule lumen • ficolin-1-rich granule lumen Biological process • purine nucleotide catabolic process • purine nucleoside metabolic process • nucleoside metabolic process • interleukin-2 secretion • inosine catabolic process • positive regulation of T cell proliferation • immune response • nicotinamide riboside catabolic process • NAD biosynthesis via nicotinamide riboside salvage pathway • nucleobase-containing compound metabolic process • positive regulation of alpha-beta T cell differentiation • response to drug • urate biosynthetic process • neutrophil degranulation • purine-containing compound salvage Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4860	667034
Ensembl	ENSG00000198805	ENSMUSG00000068417
UniProt	P00491	n/a
RefSeq (mRNA)	NM_000270	NM_001123371
RefSeq (protein)	NP_000261	n/a
Location (UCSC)	Chr 14: 20.47 – 20.48 Mb	Chr 14: 50.96 – 50.96 Mb
PubMed search

1M73, 1PF7, 1PWY, 1RCT, 1RFG, 1RR6, 1RSZ, 1RT9, 1ULA, 1ULB, 1V2H, 1V3Q, 1V41, 1V45, 1YRY, 2A0W, 2A0X, 2A0Y, 2OC4, 2OC9, 2ON6, 2Q7O, 3BGS, 3D1V, 3GB9, 3GGS, 3INY, 3K8O, 3K8Q, 3PHB, 4EAR, 4EB8, 4ECE, 4GKA