Prussian blue (medical use)
Prussian blue
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| Trade names | Radiogardase, others |
| AHFS/Drugs.com | Monograph |
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| Routes of administration |
by mouth |
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| Molar mass | 859.24 |
Prussian blue, also known as potassium ferric hexacyanoferrate, is used as a medication to treat thallium poisoning or radioactive cesium poisoning. For thallium it may be used in addition to gastric lavage, activated charcoal, forced diuresis, and hemodialysis. It is given by mouth or nasogastric tube. Prussian blue is also used in the urine to test for G6PD deficiency.
Side effects may include constipation, low blood potassium, and stools that are dark. With long term use, sweat may turn blue. It works by binding to and thus preventing the absorption of thallium and cesium from the intestines.
Prussian blue was developed around 1706. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. As of 2016 it is only approved for medical use in Germany and the United States. In the United States a course of treatment costs more than 200 USD. Access can be difficult in many areas of the world including the developed world.
Prussian blue is used to treat thallium poisoning or radioactive cesium poisoning. It may also be used for exposure to radioactive material until the underlying type is determined.
Often it is given with mannitol or sorbital to increase the speed it moves through the intestines.
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