Prostaglandin E receptor 3

PTGER3

Identifiers

PTGER3, EP3, EP3-I, EP3-II, EP3-III, EP3-IV, EP3e, PGE2-R, EP3-VI, Prostaglandin E receptor 3

External IDs

MGI: 97795 HomoloGene: 105703 GeneCards: PTGER3

Targeted by Drug

dinoprostone, dinoprost, sulprostone, treprostinil, U46619

Gene ontology
Molecular function	• G-protein coupled receptor activity • prostaglandin receptor activity • signal transducer activity • prostaglandin E receptor activity
Cellular component	• nuclear envelope • membrane • plasma membrane • integral component of plasma membrane • integral component of membrane
Biological process	• G-protein coupled receptor signaling pathway • positive regulation of fever generation • cell death • signal transduction • negative regulation of gastric acid secretion • phospholipase C-activating G-protein coupled receptor signaling pathway • intestine smooth muscle contraction
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


5733


19218

Ensembl


ENSG00000050628


ENSMUSG00000040016

UniProt


P43115


P30557

RefSeq (mRNA)

NM_000957 NM_001126044 NM_198712 NM_198713 NM_198714
NM_198715 NM_198716 NM_198717 NM_198718 NM_198719 NM_198720


NM_011196

RefSeq (protein)

NP_001119516 NP_942007 NP_942008 NP_942009 NP_942010
NP_942011 NP_942012


n/a

Location (UCSC)

Chr 1: 70.85 – 71.05 Mb

Chr 3: 157.57 – 157.65 Mb

PubMed search

NM_198715
NM_198716
NM_198717
NM_198718
NM_198719
NM_198720

NM_011196

NP_942011
NP_942012

n/a

Prostaglandin EP₃ receptor (53kDa), also known as EP₃, is a prostaglandin receptor for prostaglandin E2 (PGE₂) encoded by the human gene PTGER3; it is one of four identified EP receptors, the others being EP₁, EP₂, and EP₄, all of which bind with and mediate cellular responses to PGE₂ and also, but generally with lesser affinity and responsiveness, certain other prostanoids (see Prostaglandin receptors). EP has been implicated in various physiological and pathological responses.

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