Prostacyclin receptor

PTGIR
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4F8K
Identifiers
Aliases	PTGIR, IP, PRIPR, prostaglandin I2 (prostacyclin) receptor (IP)
External IDs	MGI: 99535 HomoloGene: 7496 GeneCards: PTGIR
Targeted by Drug
alprostadil, treprostinil, U46619
Gene ontology Molecular function • G-protein coupled receptor activity • signal transducer activity • guanyl-nucleotide exchange factor activity • prostacyclin receptor activity Cellular component • integral component of membrane • cytosol • plasma membrane • integral component of plasma membrane • membrane Biological process • negative regulation of platelet-derived growth factor receptor signaling pathway • positive regulation of cAMP biosynthetic process • cell-cell signaling • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • G-protein coupled receptor signaling pathway • response to lipopolysaccharide • negative regulation of smooth muscle cell proliferation • adenylate cyclase-activating G-protein coupled receptor signaling pathway • positive regulation of cAMP-mediated signaling • signal transduction • positive regulation of GTPase activity Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5739	19222
Ensembl	ENSG00000160013	ENSMUSG00000043017
UniProt	P43119	P43252
RefSeq (mRNA)	NM_000960	NM_008967
RefSeq (protein)	NP_000951	NP_032993.2 NP_032993
Location (UCSC)	Chr 19: 46.62 – 46.63 Mb	Chr 7: 16.91 – 16.91 Mb
PubMed search

4F8K

5739

19222

ENSG00000160013

ENSMUSG00000043017

P43119

P43252

NM_000960

NM_008967

NP_000951

NP_032993.2
NP_032993

The Prostacyclin receptor , also termed the prostaglandin I2 receptor or just IP, is a receptor belonging to the prostaglandin (PG) group of receptors. IP binds to and mediates the biological actions of prostacyclin (also termed Prostaglandin I₂, PGI₂, or when used as a drug, epoprostenol). IP is encoded in humans by the PTGIR gene. While possessing many functions as defined in animal model studies, the major clinical relevancy of IP is as a powerful vasodilator: stimulators of IP are used to treat severe and even life-threatening diseases involving pathological vasoconstriction.

The PTGIR gene is located on human chromosome 19 at position q13.32 (i.e. 19q13.32), contains 6 exons, and codes for a G protein coupled receptor (GPCR) of the rhodopsin-like receptor family, Subfamily A14 (see rhodopsin-like receptors#Subfamily A14).

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Wikipedia