Propylthiouracil

Propylthiouracil
Clinical data


AHFS/Drugs.com	Monograph
MedlinePlus	a682465
Pregnancy category	D
Routes of administration	by mouth
ATC code	H03BA02 (WHO)
Legal status
Legal status	℞ (Prescription only)
Pharmacokinetic data
Bioavailability	80%-95%
Metabolism	?
Biological half-life	2 hours
Excretion	?
Identifiers
IUPAC name 6-propyl-2-sulfanylpyrimidin-4-one
Synonyms	6-n-propylthiouracil (PROP)
CAS Number	51-52-5^Y
PubChem (CID)	657298
IUPHAR/BPS	6650
DrugBank	DB00550^Y
ChemSpider	571424^Y
UNII	721M9407IY^Y
KEGG	D00562^Y
ChEBI	CHEBI:8502^Y
ChEMBL	CHEMBL1518^Y
ECHA InfoCard	100.000.095
Chemical and physical data
Formula	C₇H₁₀N₂OS
Molar mass	170.233 g/mol
3D model (Jmol)	Interactive image
SMILES S=C1N/C(=C\C(=O)N1)CCC
InChI InChI=1S/C7H10N2OS/c1-2-3-5-4-6(10)9-7(11)8-5/h4H,2-3H2,1H3,(H2,8,9,10,11)^Y Key:KNAHARQHSZJURB-UHFFFAOYSA-N^Y

Propylthiouracil (PTU) is a medication used to treat hyperthyroidism. This includes hyperthyroidism due to Graves' disease and toxic multinodular goiter. In a thyrotoxic crisis it is generally more effective than methimazole. Otherwise it is typically only used when methimazole, surgery, and radioactive iodine is not possible. It is taken by mouth.

Common side effects include itchiness, hair loss, swelling, vomiting, muscle pains, numbness, and headache. Other severe side effects include liver problems and low blood cell counts. Use during pregnancy may harm the baby. Propylthiouracil is in the antithyroid family of medications. It works by decreasing the amount of thyroid hormone produced by the thyroid gland and blocking the conversion of thyroxine (T4) to triiodothyronine (T3).

Propylthiouracil came into medical use in the 1940s. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. The wholesale cost in the developing world is about 3.62 USD a month. In the United Kingdom a month costs the NHS about 52.51 pounds. In the United States the wholesale price is 38.34 USD per month.

Propylthiouracil is generally well tolerated, with side effects occurring in one of every 100 patients. The most common side effects are related to the skin, and include rash, itching, hives, abnormal hair loss, and skin pigmentation. Other common side effects are swelling, nausea, vomiting, heartburn, loss of taste, joint or muscle aches, numbness and headache, allergic reactions, and hair whitening.

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