Procaine benzylpenicillin
| Combination of | |
|---|---|
| Benzylpenicillin | antibiotic |
| Procaine | anaesthetic |
| Clinical data | |
| Trade names | Bicillin C-R, other |
| AHFS/Drugs.com | FDA Professional Drug Information |
| Pregnancy category |
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| Routes of administration |
IM |
| ATC code | J01CE09 (WHO) QJ51CE09 (WHO) |
| Legal status | |
| Legal status |
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| Identifiers | |
| Synonyms | penicillin G procaine, procaine penicillin G, procaine penicillin |
| CAS Number |
54-35-3 
|
| ChEMBL |
CHEMBL1628385 
|
| E number | E707 (antibiotics) |
| ECHA InfoCard | 100.000.187 |
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Procaine benzylpenicillin also known as penicillin G procaine, is an antibiotic useful for the treatment of a number of bacterial infections. Specifically it is used for syphilis, anthrax, mouth infections, pneumonia, diphtheria, cellulitis, and animal bites. It is given by injection into a muscle.
Side effects include pain at the site of injection, blood clotting problems, seizures, and allergic reactions including anaphylaxis. When used to treat syphilis a reaction known as Jarisch-Herxheimer may occur. It is not recommended in those with a history of penicillin allergy or procaine allergy. Use during pregnancy and breastfeeding is relatively safe. Procaine benzylpenicillin is in the penicillin and beta lactam family of medications. It works via benzylpenicillin and results in bacterial death. Procaine makes the combination long acting.
Procaine benzylpenicillin was introduced for medical use in 1948. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. The wholesale cost in the developing world is about 0.09 to 0.18 USD per day. In the United States a course of treatment costs 100 to 200 USD.
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