Princess Maria Immaculata Cristina Pia Isabella of Bourbon-Two Sicilies (Full Italian name: Maria Immacolata Speranza Pia Teresa Cristina Filomena Lucia Anna Isabella Cecilia Apollonia Barbara Agnese Zenobia, Principessa di Borbone delle Due Sicilie,) (30 October 1874, Cannes, France – 28 November 1947, Muri, Switzerland) was the fourth child and eldest daughter of Prince Alfonso of Bourbon-Two Sicilies, Count of Caserta and his wife Princess Maria Antonietta of Bourbon-Two Sicilies.

Maria Immaculata married Prince Johann Georg of Saxony, sixth child and second-eldest son of George of Saxony and his wife Maria Anna of Portugal, on 30 October 1906 in Cannes. Her mother-in-law, Maria Anna, was the daughter of Maria II of Portugal and her husband Ferdinand II of Portugal. The couple did not have children.